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Emerging Perspective: Role of Increased ROS and Redox Imbalance in Skin Carcinogenesis
Joint Authors
Zhong, Jianqiao
Xian, Dehai
Xiong, Xia
Lai, Rui
Song, Jing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Strategies to battle malignant tumors have always been a dynamic research endeavour.
Although various vehicles (e.g., chemotherapeutic therapy, radiotherapy, surgical resection, etc.) are used for skin cancer management, they mostly remain unsatisfactory due to the complex mechanism of carcinogenesis.
Increasing evidence indicates that redox imbalance and aberrant reactive oxygen species (ROS) are closely implicated in the oncogenesis of skin cancer.
When ROS production goes beyond their clearance, excessive or accumulated ROS could disrupt redox balance, induce oxidative stress, and activate the altered ROS signals.
These would damage cellular DNA, proteins, and lipids, further leading to gene mutation, cell hyperproliferation, and fatal lesions in cells that contribute to carcinogenesis in the skin.
It has been known that ROS-mediated skin carcinogenesis involves multiple ways, including modulating related signaling pathways, changing cell metabolism, and causing the instability of the genome and epigenome.
Nevertheless, the exact role of ROS in skin cancer has not been thoroughly elucidated.
In spite of ROS inducing skin carcinogenesis, toxic-dose ROS could trigger cell death/apoptosis and, therefore, may be an efficient therapeutic tool to battle skin cancer.
Considering the dual role of ROS in the carcinogenesis and treatment of skin cancer, it would be essential to clarify the relationship between ROS and skin cancer.
Thus, in this review, we get the related data together to seek the connection between ROS and skin carcinogenesis.
Besides, strategies basing on ROS to fight skin cancer are discussed.
American Psychological Association (APA)
Xian, Dehai& Lai, Rui& Song, Jing& Xiong, Xia& Zhong, Jianqiao. 2019. Emerging Perspective: Role of Increased ROS and Redox Imbalance in Skin Carcinogenesis. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1205471
Modern Language Association (MLA)
Xian, Dehai…[et al.]. Emerging Perspective: Role of Increased ROS and Redox Imbalance in Skin Carcinogenesis. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1205471
American Medical Association (AMA)
Xian, Dehai& Lai, Rui& Song, Jing& Xiong, Xia& Zhong, Jianqiao. Emerging Perspective: Role of Increased ROS and Redox Imbalance in Skin Carcinogenesis. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1205471
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205471