Taurine Attenuates Carcinogenicity in Ulcerative Colitis-Colorectal Cancer Mouse Model
Joint Authors
Ma, Ning
Oikawa, Shinji
Wang, Guifeng
He, Feng
Kobayashi, Hatasu
Kawanishi, Shosuke
Murata, Mariko
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Taurine (2-aminoethane-sulfonic acid) is a type of amino acids and has numerous physiological and therapeutic functions, including anti-inflammation.
However, there are few studies on the anticancer action of taurine.
Our previous studies have demonstrated that taurine exhibits an apoptosis-inducing effect on human nasopharyngeal carcinoma cells in vitro.
In this study, we have investigated whether taurine has an anticancer effect, using azoxymethane (AOM)/sulfate sodium (DSS)- induced mouse model for colon carcinogenesis.
All mice, except those in control group, received a single intraperitoneal injection of AOM and DSS in the drinking water for 7 days twice, with 1-week interval.
After the first DSS treatment, mice were given distilled water (model group) or taurine in the drinking water (taurine group) ad libitum.
No tumor was observed in the control group.
Taurine significantly suppressed AOM+DSS-induced tumor formation.
Histopathological examination revealed AOM/DSS treatment induced colon cancer in all mice (8/8, 100%), and taurine significantly inhibited the progression of colon cancer (4/9, 44.4%).
Taurine significantly attenuated cell proliferation in cancer tissues detected by Ki-67 staining.
Taurine significantly increased the levels of an apoptosis marker cleaved caspase-9 and tumor suppressor protein PTEN.
This is the first study that demonstrated that taurine significantly reduced carcinogenicity in vivo using AOM/DSS-induced colon cancer mouse model.
American Psychological Association (APA)
Wang, Guifeng& Ma, Ning& He, Feng& Kawanishi, Shosuke& Kobayashi, Hatasu& Oikawa, Shinji…[et al.]. 2020. Taurine Attenuates Carcinogenicity in Ulcerative Colitis-Colorectal Cancer Mouse Model. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1205472
Modern Language Association (MLA)
Wang, Guifeng…[et al.]. Taurine Attenuates Carcinogenicity in Ulcerative Colitis-Colorectal Cancer Mouse Model. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1205472
American Medical Association (AMA)
Wang, Guifeng& Ma, Ning& He, Feng& Kawanishi, Shosuke& Kobayashi, Hatasu& Oikawa, Shinji…[et al.]. Taurine Attenuates Carcinogenicity in Ulcerative Colitis-Colorectal Cancer Mouse Model. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1205472
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205472