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The Effect of Acepromazine Alone or in Combination with Methadone, Morphine, or Tramadol on Sedation and Selected Cardiopulmonary Variables in Sheep
Joint Authors
Nishimura, Lilian Toshiko
Villela, Isadora Oliveira Junqueira
Carvalho, Leonardo Lamarca
Borges, Luisa Pucci Bueno
Silva, Marcos Augusto Machado
Mattos-Junior, Ewaldo
Source
Veterinary Medicine International
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The sedative and selected cardiopulmonary effects of acepromazine alone or in combination with methadone, morphine, or tramadol were compared in sheep.
Six ewes were randomly assigned to treatments: A (0.05 mg/kg acepromazine), AM (A plus 0.5 mg/kg methadone), AMO (A plus 0.5 mg/kg morphine), and AT (A plus 5 mg/kg tramadol).
Parameters were assessed before sedative drug administration (baseline) and every 15 minutes thereafter, for two hours.
Treatments A and AM were associated with increases in sedation score for 60 minutes and treatments AMO and AT for 30 minutes; however, there were no significant differences between treatments.
There was a decrease in mean arterial pressure compared to baseline values in treatment A at 15, 45, 60, and 90 minutes, in treatment AM at 15 minutes, and in treatment AT from 45 to 120 minutes.
Arterial blood carbon dioxide pressure increased at all time points in all treatments.
Arterial oxygen pressure decreased in treatment AMO at 15, 30, and 120 minutes and in treatment AT at 15–45, 105, and 120 minutes, compared to baseline.
Acepromazine alone causes a level of sedation similar to that observed when it is coadministered with opioids methadone, morphine, and tramadol.
These combinations did not cause clinical cardiopulmonary changes.
American Psychological Association (APA)
Nishimura, Lilian Toshiko& Villela, Isadora Oliveira Junqueira& Carvalho, Leonardo Lamarca& Borges, Luisa Pucci Bueno& Silva, Marcos Augusto Machado& Mattos-Junior, Ewaldo. 2017. The Effect of Acepromazine Alone or in Combination with Methadone, Morphine, or Tramadol on Sedation and Selected Cardiopulmonary Variables in Sheep. Veterinary Medicine International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1205491
Modern Language Association (MLA)
Nishimura, Lilian Toshiko…[et al.]. The Effect of Acepromazine Alone or in Combination with Methadone, Morphine, or Tramadol on Sedation and Selected Cardiopulmonary Variables in Sheep. Veterinary Medicine International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1205491
American Medical Association (AMA)
Nishimura, Lilian Toshiko& Villela, Isadora Oliveira Junqueira& Carvalho, Leonardo Lamarca& Borges, Luisa Pucci Bueno& Silva, Marcos Augusto Machado& Mattos-Junior, Ewaldo. The Effect of Acepromazine Alone or in Combination with Methadone, Morphine, or Tramadol on Sedation and Selected Cardiopulmonary Variables in Sheep. Veterinary Medicine International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1205491
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205491