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Implications of Oxidative Stress and Cellular Senescence in Age-Related Thymus Involution
Joint Authors
Gorgoulis, Vassilis G.
Evangelou, Konstantinos
Vasileiou, Panagiotis
Papoudou-Bai, Alexandra
Kanavaros, Panagiotis
Barbouti, Alexandra
Vlasis, Konstantinos G.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-05
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The human thymus is a primary lymphoepithelial organ which supports the production of self-tolerant T cells with competent and regulatory functions.
Paradoxically, despite the crucial role that it exerts in T cell-mediated immunity and prevention of systemic autoimmunity, the thymus is the first organ of the body that exhibits age-associated degeneration/regression, termed “thymic involution.” A hallmark of this early phenomenon is a progressive decline of thymic mass as well as a decreased output of naïve T cells, thus resulting in impaired immune response.
Importantly, thymic involution has been recently linked with cellular senescence which is a stress response induced by various stimuli.
Accumulation of senescent cells in tissues has been implicated in aging and a plethora of age-related diseases.
In addition, several lines of evidence indicate that oxidative stress, a well-established trigger of senescence, is also involved in thymic involution, thus highlighting a possible interplay between oxidative stress, senescence, and thymic involution.
American Psychological Association (APA)
Barbouti, Alexandra& Vasileiou, Panagiotis& Evangelou, Konstantinos& Vlasis, Konstantinos G.& Papoudou-Bai, Alexandra& Gorgoulis, Vassilis G.…[et al.]. 2020. Implications of Oxidative Stress and Cellular Senescence in Age-Related Thymus Involution. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205495
Modern Language Association (MLA)
Barbouti, Alexandra…[et al.]. Implications of Oxidative Stress and Cellular Senescence in Age-Related Thymus Involution. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1205495
American Medical Association (AMA)
Barbouti, Alexandra& Vasileiou, Panagiotis& Evangelou, Konstantinos& Vlasis, Konstantinos G.& Papoudou-Bai, Alexandra& Gorgoulis, Vassilis G.…[et al.]. Implications of Oxidative Stress and Cellular Senescence in Age-Related Thymus Involution. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205495
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205495