Gender Difference on the Effect of Omega-3 Polyunsaturated Fatty Acids on Acetaminophen-Induced Acute Liver Failure
Joint Authors
Zeng, Qingchun
Zhou, Jia
Liu, Yan
Lu, Xiao
Zuo, Daming
Chen, Zhengliang
Liu, Yunzhi
Chen, Yu
Xie, Xinghuan
Yin, Aiping
Yin, Yue
Dong, Lijun
Zhu, Zhengyumeng
Wen, Kun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-27
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Acetaminophen (APAP) toxicity is the leading cause of drug-induced liver failure, which is closely related to mitochondrial dysfunction and oxidative damage.
Studies in clinical trials and in animal models have shown that omega-3 polyunsaturated fatty acids (n-3 PUFAs) affect the progression of various types of liver damage.
Interestingly, the sex-dependent effect of n-3 PUFAs on human health has also been well documented.
However, it is unknown whether supplementation of n-3 PUFAs modulates the pathogenesis of APAP-induced liver failure with sex-specificity.
Our results showed that both endogenous and exogenous n-3 PUFAs significantly aggravated the APAP-induced liver injury in male mice, whereas the opposite effects were observed in females.
In vivo and in vitro studies demonstrated that estrogen contributes to the gender difference in the regulation of n-3 PUFAs on APAP overdose.
We found that n-3 PUFA-mediated regulation of hepatic oxidative stress response and autophagy upon APAP challenge is distinct between male and female mice.
Moreover, we provided evidence that β-catenin signaling activation is responsible for the sex-dependent regulation of APAP hepatotoxicity by n-3 PUFAs.
Together, these findings indicated that supplementation with n-3 PUFAs displays sex-differential effect on APAP hepatotoxicity and could have profound significance in the clinical management for drug-induced liver injury.
American Psychological Association (APA)
Liu, Yunzhi& Chen, Yu& Xie, Xinghuan& Yin, Aiping& Yin, Yue& Liu, Yan…[et al.]. 2020. Gender Difference on the Effect of Omega-3 Polyunsaturated Fatty Acids on Acetaminophen-Induced Acute Liver Failure. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1205519
Modern Language Association (MLA)
Liu, Yunzhi…[et al.]. Gender Difference on the Effect of Omega-3 Polyunsaturated Fatty Acids on Acetaminophen-Induced Acute Liver Failure. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1205519
American Medical Association (AMA)
Liu, Yunzhi& Chen, Yu& Xie, Xinghuan& Yin, Aiping& Yin, Yue& Liu, Yan…[et al.]. Gender Difference on the Effect of Omega-3 Polyunsaturated Fatty Acids on Acetaminophen-Induced Acute Liver Failure. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1205519
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205519