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Anti-inflammatory Role of Carotenoids in Endothelial Cells Derived from Umbilical Cord of Women Affected by Gestational Diabetes Mellitus
Joint Authors
Lanuti, Paola
Ucci, Mariangela
Di Tomo, Pamela
Tritschler, Federica
Cordone, Vincenzo G. P.
Bologna, Giuseppina
Di Silvestre, Sara
Di Pietro, Natalia
Pipino, Caterina
Mandatori, Domitilla
Formoso, Gloria
Pandolfi, Assunta
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Diabetes is associated with vascular inflammation, endothelial dysfunction, and oxidative stress, promoting the development of cardiovascular diseases (CVD).
Several studies showed that a carotenoid-rich diet is associated to a reduced cardiovascular risk in healthy and diabetic subjects, although the mechanisms of action are still unknown.
Here, the potential role of β-carotene (BC) and lycopene (Lyc) in human endothelial cells isolated from human umbilical cord vein (HUVECs) of women with gestational diabetes (GD) and respective controls (C) has been investigated.
Results showed that BC and Lyc reduced the tumor necrosis factor alpha- (TNF-α-) stimulated monocyte-endothelium interaction (adhesion assay), membrane exposure (flow cytometry), and total expression levels (Western blot) of VCAM-1 and ICAM-1 in both cell types.
Moreover, the treatment with BC and Lyc reduced the TNF-α-induced nuclear translocation of NF-κB (image flow cytometry) by preserving bioavailability of nitric oxide (NO, flow cytometry, and cGMP EIA kit assay), a key vasoactive molecule.
Notably, BC and Lyc pretreatment significantly reduced peroxynitrite levels (flow cytometry), contributing to the redox balance protection.
These results suggest a new mechanism of action of carotenoids which exert vascular protective action in diabetic condition, thus reinforcing the importance of a carotenoid-rich diet in the prevention of diabetes cardiovascular complications.
American Psychological Association (APA)
Ucci, Mariangela& Di Tomo, Pamela& Tritschler, Federica& Cordone, Vincenzo G. P.& Lanuti, Paola& Bologna, Giuseppina…[et al.]. 2019. Anti-inflammatory Role of Carotenoids in Endothelial Cells Derived from Umbilical Cord of Women Affected by Gestational Diabetes Mellitus. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1205527
Modern Language Association (MLA)
Ucci, Mariangela…[et al.]. Anti-inflammatory Role of Carotenoids in Endothelial Cells Derived from Umbilical Cord of Women Affected by Gestational Diabetes Mellitus. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1205527
American Medical Association (AMA)
Ucci, Mariangela& Di Tomo, Pamela& Tritschler, Federica& Cordone, Vincenzo G. P.& Lanuti, Paola& Bologna, Giuseppina…[et al.]. Anti-inflammatory Role of Carotenoids in Endothelial Cells Derived from Umbilical Cord of Women Affected by Gestational Diabetes Mellitus. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1205527
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205527