lncRNA AK054386 Functions as a ceRNA to Sequester miR-199 and Induce Sustained Endoplasmic Reticulum Stress in Hepatic Reperfusion Injury
Joint Authors
Yue, Wang
Dai, Binghua
Qiao, Liang
Zhang, Mingke
Cheng, Lipeng
Zhang, Ling
Geng, Li
Shi, Changying
Zhang, Minfeng
Sui, Chengjun
Shen, Weifeng
Sun, Yanfu
Chen, Qian
Hui, Dong
Yang, Jiamei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-13
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Hepatic ischemia-reperfusion injury (IRI) is a very complex pathological process that is often associated with liver trauma and surgery, especially liver transplantation surgery.
Although endoplasmic reticulum stress (ERS) plays a role in this process, the posttranscriptional regulators and the underlying mechanisms are still unclear.
Here, we report that the lncRNA AK054386 was increased in hepatic IRI models.
Furthermore, AK054386 can act as a “competing endogenous RNA (ceRNA)” and regulate ERS-related factors by binding and sequestering miR-199, which was shown to inhibit ERS in our previous report.
Increased expression of AK054386, which might be mediated by activated NF-κB, resulted in sustained ERS and increased cell apoptosis and death in hepatic IRI mouse and cellular models.
In contrast, AK054386 inhibition had protective effects on these models.
Our data indicate that AK054386 and miR-199 are critical players in hepatic IRI, and we broadened the scope regarding ceRNA mechanisms.
We hope that our results will improve the understanding of hepatic IRI and may provide potential therapeutic targets.
American Psychological Association (APA)
Dai, Binghua& Qiao, Liang& Zhang, Mingke& Cheng, Lipeng& Zhang, Ling& Geng, Li…[et al.]. 2019. lncRNA AK054386 Functions as a ceRNA to Sequester miR-199 and Induce Sustained Endoplasmic Reticulum Stress in Hepatic Reperfusion Injury. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1205533
Modern Language Association (MLA)
Dai, Binghua…[et al.]. lncRNA AK054386 Functions as a ceRNA to Sequester miR-199 and Induce Sustained Endoplasmic Reticulum Stress in Hepatic Reperfusion Injury. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1205533
American Medical Association (AMA)
Dai, Binghua& Qiao, Liang& Zhang, Mingke& Cheng, Lipeng& Zhang, Ling& Geng, Li…[et al.]. lncRNA AK054386 Functions as a ceRNA to Sequester miR-199 and Induce Sustained Endoplasmic Reticulum Stress in Hepatic Reperfusion Injury. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1205533
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205533