Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications
Joint Authors
Piccoli, Claudia
Tataranni, Tiziana
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-14
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
An extensive body of literature describes anticancer property of dichloroacetate (DCA), but its effective clinical administration in cancer therapy is still limited to clinical trials.
The occurrence of side effects such as neurotoxicity as well as the suspicion of DCA carcinogenicity still restricts the clinical use of DCA.
However, in the last years, the number of reports supporting DCA employment against cancer increased also because of the great interest in targeting metabolism of tumour cells.
Dissecting DCA mechanism of action helped to understand the bases of its selective efficacy against cancer cells.
A successful coadministration of DCA with conventional chemotherapy, radiotherapy, other drugs, or natural compounds has been tested in several cancer models.
New drug delivery systems and multiaction compounds containing DCA and other drugs seem to ameliorate bioavailability and appear more efficient thanks to a synergistic action of multiple agents.
The spread of reports supporting the efficiency of DCA in cancer therapy has prompted additional studies that let to find other potential molecular targets of DCA.
Interestingly, DCA could significantly affect cancer stem cell fraction and contribute to cancer eradication.
Collectively, these findings provide a strong rationale towards novel clinical translational studies of DCA in cancer therapy.
American Psychological Association (APA)
Tataranni, Tiziana& Piccoli, Claudia. 2019. Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1205542
Modern Language Association (MLA)
Tataranni, Tiziana& Piccoli, Claudia. Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1205542
American Medical Association (AMA)
Tataranni, Tiziana& Piccoli, Claudia. Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1205542
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205542