Inhibition of Mitochondrial ROS by MitoQ Alleviates White Matter Injury and Improves Outcomes after Intracerebral Haemorrhage in Mice
Joint Authors
Liu, Xin
Feng, Hua
Chen, Yujie
Chen, Weixiang
Hu, Rong
Guo, Chao
Jia, Zhengcai
Wang, Jie
Xia, Min
Li, Chengcheng
Li, Mingxi
Yin, Yi
Tang, Xiaoqin
Chen, Tunan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
White matter injury (WMI) is an important cause of high disability after intracerebral haemorrhage (ICH).
It is widely accepted that reactive oxygen species (ROS) contributes to WMI, but there is still no evidence-based treatment.
Here, mitoquinone (MitoQ), a newly developed selective mitochondrial ROS scavenger, was used to test its neuroprotective potential.
The data showed that MitoQ attenuated motor function deficits and motor-evoked potential (MEP) latency prolongation.
Further research found that MitoQ blunted the loss of oligodendrocytes and oligodendrocyte precursor cells, therefore reduced demyelination and axon swelling after ICH.
In the in vitro experiments, MitoQ, but not the nonselective antioxidant, almost completely attenuated the iron-induced membrane potential decrease and cell death.
Mechanistically, MitoQ blocked the ATP deletion and mitochondrial ROS overproduction.
The present study demonstrates that the selective mitochondrial ROS scavenger MitoQ may improve the efficacy of antioxidant treatment of ICH by white matter injury alleviation.
American Psychological Association (APA)
Chen, Weixiang& Guo, Chao& Jia, Zhengcai& Wang, Jie& Xia, Min& Li, Chengcheng…[et al.]. 2020. Inhibition of Mitochondrial ROS by MitoQ Alleviates White Matter Injury and Improves Outcomes after Intracerebral Haemorrhage in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205563
Modern Language Association (MLA)
Chen, Weixiang…[et al.]. Inhibition of Mitochondrial ROS by MitoQ Alleviates White Matter Injury and Improves Outcomes after Intracerebral Haemorrhage in Mice. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1205563
American Medical Association (AMA)
Chen, Weixiang& Guo, Chao& Jia, Zhengcai& Wang, Jie& Xia, Min& Li, Chengcheng…[et al.]. Inhibition of Mitochondrial ROS by MitoQ Alleviates White Matter Injury and Improves Outcomes after Intracerebral Haemorrhage in Mice. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205563
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205563