Role of Prefrontal Cortex on Recognition Memory Deficits in Rats following 6-OHDA-Induced Locus Coeruleus Lesion
Joint Authors
Prediger, Rui Daniel
Sampaio, Tuane Bazanella
Marques, Naiani Ferreira
Binder, Luisa Bandeira
Tasca, Carla Inês
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Degeneration of the locus coeruleus (LC), the main source of cerebral noradrenaline (NA), has been reported in diverse neurodegenerative diseases, including Parkinson’s diseases (PD).
There is increasing evidence indicating the role of NA deficiency in the prefrontal cortex (PFC) and the development of early cognitive impairments in PD.
Here, we evaluated whether a selective noradrenergic lesion of LC caused by 6-hydroxydopamine (6-OHDA) may induce memory deficits and neurochemical alterations in the PFC.
Adult male Wistar rats received stereotaxic bilateral injections of 6-OHDA (5 μg/2 μl) into the LC, and two stainless-steel guide cannulas were implanted in the PFC.
The SHAM group received just vehicle.
To induce a selective noradrenergic lesion, animals received nomifensine (10 mg/kg), a dopamine transporter blocker, one hour before surgery.
6-OHDA-lesioned rats displayed impairments of the short- and long-term object recognition memory associated to reduced content of tyrosine hydroxylase in the LC.
Neurochemical analysis revealed an altered mitochondrial membrane potential in LC.
Regarding the PFC, an increased ROS production, cell membrane damage, and mitochondrial membrane potential disruption were observed.
Remarkably, bilateral NA (1 μg/0.2 μl) infusion into the PFC restored the recognition memory deficits in LC-lesioned rats.
These findings indicate that a selective noradrenergic LC lesion induced by 6-OHDA deregulates a noradrenergic network in the PFC, which could be involved in the early memory impairments observed in nondemented PD patients.
American Psychological Association (APA)
Sampaio, Tuane Bazanella& Marques, Naiani Ferreira& Binder, Luisa Bandeira& Tasca, Carla Inês& Prediger, Rui Daniel. 2020. Role of Prefrontal Cortex on Recognition Memory Deficits in Rats following 6-OHDA-Induced Locus Coeruleus Lesion. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205572
Modern Language Association (MLA)
Sampaio, Tuane Bazanella…[et al.]. Role of Prefrontal Cortex on Recognition Memory Deficits in Rats following 6-OHDA-Induced Locus Coeruleus Lesion. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1205572
American Medical Association (AMA)
Sampaio, Tuane Bazanella& Marques, Naiani Ferreira& Binder, Luisa Bandeira& Tasca, Carla Inês& Prediger, Rui Daniel. Role of Prefrontal Cortex on Recognition Memory Deficits in Rats following 6-OHDA-Induced Locus Coeruleus Lesion. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205572
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205572