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Common Protective Strategies in Neurodegenerative Disease: Focusing on Risk Factors to Target the Cellular Redox System
Joint Authors
Molteni, Raffaella
Marino, Angela
Sita, Giulia
Ziche, Marina
Ristori, Emma
Cordaro, Marika
Spero, Vittoria
Hrelia, Patrizia
Malaguti, Marco
Morroni, Fabiana
Hrelia, Silvana
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-03
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Neurodegenerative disease is an umbrella term for different conditions which primarily affect the neurons in the human brain.
In the last century, significant research has been focused on mechanisms and risk factors relevant to the multifaceted etiopathogenesis of neurodegenerative diseases.
Currently, neurodegenerative diseases are incurable, and the treatments available only control the symptoms or delay the progression of the disease.
This review is aimed at characterizing the complex network of molecular mechanisms underpinning acute and chronic neurodegeneration, focusing on the disturbance in redox homeostasis, as a common mechanism behind five pivotal risk factors: aging, oxidative stress, inflammation, glycation, and vascular injury.
Considering the complex multifactorial nature of neurodegenerative diseases, a preventive strategy able to simultaneously target multiple risk factors and disease mechanisms at an early stage is most likely to be effective to slow/halt the progression of neurodegenerative diseases.
American Psychological Association (APA)
Hrelia, Patrizia& Sita, Giulia& Ziche, Marina& Ristori, Emma& Marino, Angela& Cordaro, Marika…[et al.]. 2020. Common Protective Strategies in Neurodegenerative Disease: Focusing on Risk Factors to Target the Cellular Redox System. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1205591
Modern Language Association (MLA)
Hrelia, Patrizia…[et al.]. Common Protective Strategies in Neurodegenerative Disease: Focusing on Risk Factors to Target the Cellular Redox System. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-18.
https://search.emarefa.net/detail/BIM-1205591
American Medical Association (AMA)
Hrelia, Patrizia& Sita, Giulia& Ziche, Marina& Ristori, Emma& Marino, Angela& Cordaro, Marika…[et al.]. Common Protective Strategies in Neurodegenerative Disease: Focusing on Risk Factors to Target the Cellular Redox System. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1205591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205591