Protective Activities of Dendrobium huoshanense C. Z. Tang et S. J. Cheng Polysaccharide against High-Cholesterol Diet-Induced Atherosclerosis in Zebrafish
Joint Authors
Han, Jichun
Wang, Feng
Gu, Yue
Fan, Xiangcheng
Zhu, Lijun
Chen, Zhipeng
Li, Jiajing
Wang, Tao
Yue, Yunyun
Shang, Jing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cardiovascular disease is the highest cause of death, and atherosclerosis (AS) is the primary pathogenesis of many cardiovascular diseases.
In this study, we aim to investigate the possible pharmaceutical effects of Dendrobium huoshanense C.
Z.
Tang et S.
J.
Cheng polysaccharide (DHP) in AS.
We fed zebrafish with high-cholesterol diet (HCD) to establish a zebrafish AS model and treated with DHP and observed plaque formation and neutrophil counts under a fluorescence microscope.
Next, a parallel flow chamber was utilized to establish low shear stress- (LSS-) induced endothelial cell (EC) dysfunction model.
We observed that DHP significantly improved HCD-induced lipid deposition, oxidative stress, and inflammatory response, mainly showing that DHP significantly increased superoxide dismutase (SOD) activity, decreased plaque formation, and decreased neutrophil recruitment and the levels of total cholesterol (TC), triglyceride (TG), malondialdehyde (MDA), and reactive oxygen species (ROS).
Furthermore, DHP significantly improved LSS-induced oxidative stress and EC dysfunction.
Our results indicated that DHP can exert treatment effects on AS, which may attribute to its hypolipidemic, antioxidant, anti-inflammatory activities and improving LSS-induced EC dysfunction.
DHP has promising potential for further development as a functional natural medicine source targeted at AS prevention.
American Psychological Association (APA)
Fan, Xiangcheng& Han, Jichun& Zhu, Lijun& Chen, Zhipeng& Li, Jiajing& Gu, Yue…[et al.]. 2020. Protective Activities of Dendrobium huoshanense C. Z. Tang et S. J. Cheng Polysaccharide against High-Cholesterol Diet-Induced Atherosclerosis in Zebrafish. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205593
Modern Language Association (MLA)
Fan, Xiangcheng…[et al.]. Protective Activities of Dendrobium huoshanense C. Z. Tang et S. J. Cheng Polysaccharide against High-Cholesterol Diet-Induced Atherosclerosis in Zebrafish. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1205593
American Medical Association (AMA)
Fan, Xiangcheng& Han, Jichun& Zhu, Lijun& Chen, Zhipeng& Li, Jiajing& Gu, Yue…[et al.]. Protective Activities of Dendrobium huoshanense C. Z. Tang et S. J. Cheng Polysaccharide against High-Cholesterol Diet-Induced Atherosclerosis in Zebrafish. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205593