Ameliorative Effect of Sinapic Acid on Dextran Sodium Sulfate- (DSS-) Induced Ulcerative Colitis in Kunming (KM) Mice
Joint Authors
Qian, Bo
Wang, Chengqiang
Zeng, Zhen
Ren, Yuan
Li, Dayu
Song, Jia-Le
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Ulcerative colitis is a chronic gastrointestinal disease characterized by intestinal inflammation and serious mucosal damage.
As a naturally hydroxycinnamic acid, sinapic acid (SA) has antioxidant, anticancer, and neuroprotective activities.
We investigated the anticolitic effect and potential mechanisms of SA in DSS-induced colitis in Kunming (KM) mice.
SA treatment significantly reduced body weight loss, colon shortening, and intestinal wall thickening in colitis mice.
SA treatment also significantly reduced the histological infiltration of inflammatory cells and decreased myeloperoxidase (MPO) activity in the colons of colitis mice.
The administration of SA attenuated oxidative damage by enhancing the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase and reduced the serum and colonic mRNA levels of proinflammatory cytokines in colitis mice.
We used qRT-PCR and Western blotting assays and demonstrated that SA reduced the activation of the NLRP3 inflammasome and attenuated intestinal permeability by enhancing the expression of ZO-1, occludin, and claudin-1 in colitis mice.
Here, we conclude that SA exhibits great anticolitic activity against DSS-induced colitis by enhancing the activity of antioxidant enzymes, reducing intestinal inflammation, and maintaining the intestinal barrier.
Finally, we suggest that SA may be a safe adjuvant for the prevention of clinical colitis.
American Psychological Association (APA)
Qian, Bo& Wang, Chengqiang& Zeng, Zhen& Ren, Yuan& Li, Dayu& Song, Jia-Le. 2020. Ameliorative Effect of Sinapic Acid on Dextran Sodium Sulfate- (DSS-) Induced Ulcerative Colitis in Kunming (KM) Mice. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1205600
Modern Language Association (MLA)
Qian, Bo…[et al.]. Ameliorative Effect of Sinapic Acid on Dextran Sodium Sulfate- (DSS-) Induced Ulcerative Colitis in Kunming (KM) Mice. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1205600
American Medical Association (AMA)
Qian, Bo& Wang, Chengqiang& Zeng, Zhen& Ren, Yuan& Li, Dayu& Song, Jia-Le. Ameliorative Effect of Sinapic Acid on Dextran Sodium Sulfate- (DSS-) Induced Ulcerative Colitis in Kunming (KM) Mice. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1205600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205600