Topical Application of Fibroblast Growth Factor 10-PLGA Microsphere Accelerates Wound Healing via Inhibition of ER Stress
Joint Authors
Xu, Ke
Chai, Bo
Zhang, Kailun
Xiong, Jun
Zhu, Yiru
Xu, Jingyu
An, Ningchen
Xia, Weidong
Ji, Hao
Wu, Yanqing
Li, Hao
Xiao, Jian
Feng, Zhiguo
Zhang, Hongyu
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
There is a high incidence of acute and chronic skin defects caused by various reasons in clinically practice.
The repair and functional reconstruction of skin defects have become a major clinical problem, which needs to be solved urgently.
Previous studies have shown that fibroblast growth factor 10 (FGF10) plays a functional role in promoting the proliferation, migration, and differentiation of epithelial cells.
However, little is known about the effect of FGF10 on the recovery process after skin damage.
In this study, we found that the expression of endogenous FGF10 was increased during wound healing.
We prepared FGF10-loaded poly(lactic-co-glycolic acid) (FGF10-PLGA) microspheres, and it could sustain release of FGF10 both in vitro and in vivo, accelerating wound healing.
Further analysis revealed that compared with FGF10 alone, FGF10-PLGA microspheres significantly improved granulation formation, collagen synthesis, cell proliferation, and blood vessel density.
In the meantime, we found that FGF10-PLGA microspheres inhibited the expression of endoplasmic reticulum (ER) stress markers.
Notably, activating ER stress with tunicamycin (TM) reduced therapeutic effects of FGF10-PLGA microspheres in wound healing, whereas inhibition of ER stress with 4-phenyl butyric acid (4-PBA) improved the function of FGF10-PLGA microspheres.
Taken together, this study indicates that FGF10-PLGA microspheres accelerate wound healing presumably through modulating ER stress.
American Psychological Association (APA)
Xu, Ke& Chai, Bo& Zhang, Kailun& Xiong, Jun& Zhu, Yiru& Xu, Jingyu…[et al.]. 2020. Topical Application of Fibroblast Growth Factor 10-PLGA Microsphere Accelerates Wound Healing via Inhibition of ER Stress. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1205645
Modern Language Association (MLA)
Xu, Ke…[et al.]. Topical Application of Fibroblast Growth Factor 10-PLGA Microsphere Accelerates Wound Healing via Inhibition of ER Stress. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1205645
American Medical Association (AMA)
Xu, Ke& Chai, Bo& Zhang, Kailun& Xiong, Jun& Zhu, Yiru& Xu, Jingyu…[et al.]. Topical Application of Fibroblast Growth Factor 10-PLGA Microsphere Accelerates Wound Healing via Inhibition of ER Stress. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1205645
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205645