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Green Tea Extract Ameliorates Ischemia-Induced Retinal Ganglion Cell Degeneration in Rats
Joint Authors
Pang, Chi-Pui
Sun, Xinghuai
Ng, Tsz Kin
Xu, Yanxuan
Liang, Jiajian
Yang, Yaping
Xu, Ciyan
Chen, Yuhong
Chen, Shao-Lang
Huang, Shaofen
Yang, Qichen
Cen, Ling-Ping
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
Oxidative stress induced by reduced blood circulation is a critical pathological damage to retinal ganglion cells (RGCs) in glaucoma.
We previously showed that green tea extract (GTE) and its catechin constituents alleviate sodium iodate-induced retinal degeneration in rats.
Here, we investigated the therapeutic effect of GTE on ischemia-induced RGC degeneration in rats.
Methods.
RGC degeneration was induced by ischemic reperfusion in adult Fischer F344 rats.
Green tea extract (Theaphenon E) was intragastrically administered 4 times within 48 hours after ischemia.
RGC survival, pupillary light reflex, expressions of cell apoptosis, oxidative stress, and inflammation-related proteins were studied.
Results.
Ischemic reperfusion significantly induced apoptotic RGCs, RGC loss, and larger constricted pupil area compared to the untreated normal rats.
Expressions of activated caspase-3 and caspase-8, Sod2, and inflammation-related proteins as well as p38 phosphorylation were significantly upregulated in the ischemia-injured rats.
Compared to the saline-fed ischemic rats, significantly higher number of surviving RGCs, less apoptotic RGCs, and smaller constricted pupil area were observed in the GTE-fed ischemic rats.
GTE also reduced the increased protein expressions caused by ischemic injury but enhanced the Jak phosphorylation in the retina.
Notably, green tea extract did not affect the survival of RGCs in the uninjured normal rats.
Conclusions.
In summary, GTE offers neuroprotection to RGCs under ischemic challenge, suggesting a potential therapeutic strategy for glaucoma and optic neuropathies.
American Psychological Association (APA)
Yang, Yaping& Xu, Ciyan& Chen, Yuhong& Liang, Jiajian& Xu, Yanxuan& Chen, Shao-Lang…[et al.]. 2019. Green Tea Extract Ameliorates Ischemia-Induced Retinal Ganglion Cell Degeneration in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1205650
Modern Language Association (MLA)
Yang, Yaping…[et al.]. Green Tea Extract Ameliorates Ischemia-Induced Retinal Ganglion Cell Degeneration in Rats. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1205650
American Medical Association (AMA)
Yang, Yaping& Xu, Ciyan& Chen, Yuhong& Liang, Jiajian& Xu, Yanxuan& Chen, Shao-Lang…[et al.]. Green Tea Extract Ameliorates Ischemia-Induced Retinal Ganglion Cell Degeneration in Rats. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1205650
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205650