Posttranslational Modifications in Ferroptosis
Joint Authors
Yi, Xin
Wei, Xiang
Zhu, Xue-Hai
Jiang, Ding-Sheng
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Ferroptosis was first coined in 2012 to describe the form of regulated cell death (RCD) characterized by iron-dependent lipid peroxidation.
To date, ferroptosis has been implicated in many diseases, such as carcinogenesis, degenerative diseases (e.g., Huntington’s, Alzheimer’s, and Parkinson’s diseases), ischemia-reperfusion injury, and cardiovascular diseases.
Previous studies have identified numerous targets involved in ferroptosis; for example, acyl-CoA synthetase long-chain family member 4 (ACSL4) and p53 induce while glutathione peroxidase 4 (GPX4) and apoptosis-inducing factor mitochondria-associated 2 (AIFM2, also known as FSP1) inhibit ferroptosis.
At least three major pathways (the glutathione-GPX4, FSP1-coenzyme Q10 (CoQ10), and GTP cyclohydrolase-1- (GCH1-) tetrahydrobiopterin (BH4) pathways) have been identified to participate in ferroptosis regulation.
Recent advances have also highlighted the crucial roles of posttranslational modifications (PTMs) of proteins in ferroptosis.
Here, we summarize the recently discovered knowledge regarding the mechanisms underlying ferroptosis, particularly the roles of PTMs in ferroptosis regulation.
American Psychological Association (APA)
Wei, Xiang& Yi, Xin& Zhu, Xue-Hai& Jiang, Ding-Sheng. 2020. Posttranslational Modifications in Ferroptosis. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205751
Modern Language Association (MLA)
Wei, Xiang…[et al.]. Posttranslational Modifications in Ferroptosis. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1205751
American Medical Association (AMA)
Wei, Xiang& Yi, Xin& Zhu, Xue-Hai& Jiang, Ding-Sheng. Posttranslational Modifications in Ferroptosis. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205751
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205751