Mitochondria-Targeted Antioxidants: A Step towards Disease Treatment
Joint Authors
Yin, Yulong
Yao, Kang
Chen, Jiashun
Wu, Miaomiao
Yin, Jie
Jiang, Qian
Ma, Xiaokang
Liu, Gang
Tan, Bie
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-07
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Mitochondria are the main organelles that produce adenosine 5′-triphosphate (ATP) and reactive oxygen species (ROS) in eukaryotic cells and meanwhile susceptible to oxidative damage.
The irreversible oxidative damage in mitochondria has been implicated in various human diseases.
Increasing evidence indicates the therapeutic potential of mitochondria-targeted antioxidants (MTAs) for oxidative damage-associated diseases.
In this article, we introduce the advantageous properties of MTAs compared with the conventional (nontargeted) ones, review different mitochondria-targeted delivery systems and antioxidants, and summarize their experimental results for various disease treatments in different animal models and clinical trials.
The combined evidence demonstrates that mitochondrial redox homeostasis is a potential target for disease treatment.
Meanwhile, the limitations and prospects for exploiting MTAs are discussed, which might pave ways for further trial design and drug development.
American Psychological Association (APA)
Jiang, Qian& Yin, Jie& Chen, Jiashun& Ma, Xiaokang& Wu, Miaomiao& Liu, Gang…[et al.]. 2020. Mitochondria-Targeted Antioxidants: A Step towards Disease Treatment. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1205760
Modern Language Association (MLA)
Jiang, Qian…[et al.]. Mitochondria-Targeted Antioxidants: A Step towards Disease Treatment. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-18.
https://search.emarefa.net/detail/BIM-1205760
American Medical Association (AMA)
Jiang, Qian& Yin, Jie& Chen, Jiashun& Ma, Xiaokang& Wu, Miaomiao& Liu, Gang…[et al.]. Mitochondria-Targeted Antioxidants: A Step towards Disease Treatment. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1205760
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205760