Oxidative Balance and Inflammation in Hemodialysis Patients: Biomarkers of Cardiovascular Risk?
Joint Authors
La Russa, D.
Pellegrino, D.
Montesanto, Alberto
Gigliotti, Paolo
Perri, Anna
Russa, Antonella La
Bonofiglio, Renzo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
During chronic kidney disease, the progressive deterioration of renal function induces several biological/clinical dysfunctions, including enhancement of synthesis of inflammation/oxidative stress mediators.
Impaired renal function is an independent cardiovascular risk factor; indeed, cardiovascular complications dominate the landscape of both chronic kidney disease and end-stage renal disease.
The aim of this study is to explore the correlation between the global oxidative balance in hemodialysis patients and both inflammatory markers and cardiovascular events.
Using photometric tests, this study explored plasmatic oxidative balance in 97 hemodialysis patients compared to a healthy population.
In the hemodialysis patients, we showed that oxidative stress values were significantly lower than in controls while effectiveness in the antioxidant barrier was significantly increased in the hemodialysis group.
Furthermore, we highlighted a strong correlation between oxidative index and blood levels of C-reactive protein.
When patients were divided into two groups based on previous cardiovascular events, we found that subjects with previous cardiovascular events had higher values of both oxidative stress and antioxidant barrier than patients without cardiovascular events.
Our results indicated that in hemodialysis patients, the clinical and prognostic significance of oxidative status is very different from general population.
As cardiovascular complications represent a strong negative factor for survival of hemodialysis patients, the research of new cardiovascular risk biomarkers in these patients takes on particular importance in order to translate them into clinical practice/primary care.
American Psychological Association (APA)
La Russa, D.& Pellegrino, D.& Montesanto, Alberto& Gigliotti, Paolo& Perri, Anna& Russa, Antonella La…[et al.]. 2019. Oxidative Balance and Inflammation in Hemodialysis Patients: Biomarkers of Cardiovascular Risk?. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1205778
Modern Language Association (MLA)
La Russa, D.…[et al.]. Oxidative Balance and Inflammation in Hemodialysis Patients: Biomarkers of Cardiovascular Risk?. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1205778
American Medical Association (AMA)
La Russa, D.& Pellegrino, D.& Montesanto, Alberto& Gigliotti, Paolo& Perri, Anna& Russa, Antonella La…[et al.]. Oxidative Balance and Inflammation in Hemodialysis Patients: Biomarkers of Cardiovascular Risk?. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1205778
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205778