Fluid Intake Restriction Concomitant to Sweetened Beverages Hydration Induce Kidney Damage
Joint Authors
Johnson, Richard J.
Tapia, Edilia
Muñoz-Jiménez, Itzel
Sánchez-Lozada, L. Gabriela
García-Arroyo, Fernando E.
Gonzaga-Sánchez, Guillermo
Arellano-Buendía, Abraham S.
Osorio-Alonso, Horacio
Manterola-Romero, Lino
Roncal-Jiménez, Carlos A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Currently, there is the paradox of low water intake but increased intake of sugar-sweetened beverages (SB) in several populations; those habits are associated with an increased prevalence of metabolic derangements and greater chronic disease mortality.
Persistent heat dehydration and increased SB intake stimulate the continued release of vasopressin and overactivation of the polyol-fructokinase pathway, synergizing each other, an effect partially mediated by oxidative stress.
The objective of the present study was to evaluate whether water restriction concurrent with SB hydration can cause renal damage by stimulating similar pathways as heat dehydration.
Three groups of male Wistar rats (n=6) were fluid restricted; from 10 am to 12 pm animals could rehydrate with tap water (W), or sweetened beverages, one prepared with 11% of a fructose-glucose combination (SB), or with the noncaloric edulcorant stevia (ST).
A normal control group of healthy rats was also studied.
The animals were followed for 4 weeks.
Markers of dehydration and renal damage were evaluated at the end of the study.
Fluid restriction and water hydration mildly increased urine osmolality and induced a 15% fall in CrCl while increased the markers of tubular damage by NAG and KIM-1.
Such changes were in association with a mild overexpression of V1a and V2 renal receptors, polyol fructokinase pathway overactivation, and increased renal oxidative stress with reduced expression of antioxidant enzymes.
Hydration with SB significantly amplified those alterations, while in stevia hydrated rats, the changes were similar to the ones observed in water hydrated rats.
These data suggest that current habits of hydration could be a risk factor in developing kidney damage.
American Psychological Association (APA)
García-Arroyo, Fernando E.& Tapia, Edilia& Muñoz-Jiménez, Itzel& Gonzaga-Sánchez, Guillermo& Arellano-Buendía, Abraham S.& Osorio-Alonso, Horacio…[et al.]. 2020. Fluid Intake Restriction Concomitant to Sweetened Beverages Hydration Induce Kidney Damage. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205782
Modern Language Association (MLA)
García-Arroyo, Fernando E.…[et al.]. Fluid Intake Restriction Concomitant to Sweetened Beverages Hydration Induce Kidney Damage. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1205782
American Medical Association (AMA)
García-Arroyo, Fernando E.& Tapia, Edilia& Muñoz-Jiménez, Itzel& Gonzaga-Sánchez, Guillermo& Arellano-Buendía, Abraham S.& Osorio-Alonso, Horacio…[et al.]. Fluid Intake Restriction Concomitant to Sweetened Beverages Hydration Induce Kidney Damage. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205782
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205782