Potential Applications of NRF2 Inhibitors in Cancer Therapy
Joint Authors
Panieri, Emiliano
Saso, Luciano
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-34, 34 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-11
Country of Publication
Egypt
No. of Pages
34
Main Subjects
Abstract EN
The NRF2/KEAP1 pathway represents one of the most important cell defense mechanisms against exogenous or endogenous stressors.
Indeed, by increasing the expression of several cytoprotective genes, the transcription factor NRF2 can shelter cells and tissues from multiple sources of damage including xenobiotic, electrophilic, metabolic, and oxidative stress.
Importantly, the aberrant activation or accumulation of NRF2, a common event in many tumors, confers a selective advantage to cancer cells and is associated to malignant progression, therapy resistance, and poor prognosis.
Hence, in the last years, NRF2 has emerged as a promising target in cancer treatment and many efforts have been made to identify therapeutic strategies aimed at disrupting its prooncogenic role.
By summarizing the results from past and recent studies, in this review, we provide an overview concerning the NRF2/KEAP1 pathway, its biological impact in solid and hematologic malignancies, and the molecular mechanisms causing NRF2 hyperactivation in cancer cells.
Finally, we also describe some of the most promising therapeutic approaches that have been successfully employed to counteract NRF2 activity in tumors, with a particular emphasis on the development of natural compounds and the adoption of drug repurposing strategies.
American Psychological Association (APA)
Panieri, Emiliano& Saso, Luciano. 2019. Potential Applications of NRF2 Inhibitors in Cancer Therapy. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-34.
https://search.emarefa.net/detail/BIM-1205796
Modern Language Association (MLA)
Panieri, Emiliano& Saso, Luciano. Potential Applications of NRF2 Inhibitors in Cancer Therapy. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-34.
https://search.emarefa.net/detail/BIM-1205796
American Medical Association (AMA)
Panieri, Emiliano& Saso, Luciano. Potential Applications of NRF2 Inhibitors in Cancer Therapy. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-34.
https://search.emarefa.net/detail/BIM-1205796
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205796