Studies of the Anti-amnesic Effects and Mechanisms of Single and Combined Use of Donepezil and Ginkgo Ketoester Tablet on Scopolamine-Induced Memory Impairment in Mice
Joint Authors
Zhou, Gui-Sheng
Tang, Yu-Ping
Duan, Jinao
Ma, Jiayan
Zhang, Jing
Tao, Hui-Juan
Wang, Jun
Tan, Ya-Jie
Chen, Jia-Qian
Pu, Zong-Jin
She, Wen
Kang, An
Zhu, Yue
Liu, Pei
Zhu, Zhen-Hua
Shi, Xu-Qin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-18
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Ginkgo ketoester tablets (GT) and donepezil were a clinically used combination for the treatment of Alzheimer’s disease (AD).
The aim of the study was undertaken to investigate the antiamnesic effects of the two drugs alone and in combination through in vivo models of the Morris water maze along with in vitro antioxidants, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE).
The potential mechanisms were speculated by the activities of acetylcholine (ACh), AChE, superoxide dismutase (SOD), and malondialdehyde (MDA) and the protein expression of brain-derived neurotrophic factor (BDNF) and tyrosine protein kinase B (TrkB).
The combination group showed a concentration-dependent inhibition of cholinesterase and antioxidation.
As far as its mechanism was concerned, the combination of two drugs exerted excellent effects on oxidative stress, cholinergic pathway damage, and inactivation of the BDNF-TrkB signaling pathway.
Additionally, to elucidate the binding mechanism of GT active ingredients into the structure of AChE, the results of molecular docking studies indicated that hydrogen and/or hydrophobic bonds might play an important role in their binding process.
Thus, the combination of drugs could treat AD perfectly and further verify the scientific rationality of clinical medication.
American Psychological Association (APA)
Zhang, Jing& Wang, Jun& Zhou, Gui-Sheng& Tan, Ya-Jie& Tao, Hui-Juan& Chen, Jia-Qian…[et al.]. 2019. Studies of the Anti-amnesic Effects and Mechanisms of Single and Combined Use of Donepezil and Ginkgo Ketoester Tablet on Scopolamine-Induced Memory Impairment in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1205809
Modern Language Association (MLA)
Zhang, Jing…[et al.]. Studies of the Anti-amnesic Effects and Mechanisms of Single and Combined Use of Donepezil and Ginkgo Ketoester Tablet on Scopolamine-Induced Memory Impairment in Mice. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1205809
American Medical Association (AMA)
Zhang, Jing& Wang, Jun& Zhou, Gui-Sheng& Tan, Ya-Jie& Tao, Hui-Juan& Chen, Jia-Qian…[et al.]. Studies of the Anti-amnesic Effects and Mechanisms of Single and Combined Use of Donepezil and Ginkgo Ketoester Tablet on Scopolamine-Induced Memory Impairment in Mice. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1205809
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205809