![](/images/graphics-bg.png)
Blue Light Irradiation Induces Human Keratinocyte Cell Damage via Transient Receptor Potential Vanilloid 1 (TRPV1) Regulation
Joint Authors
Kwon, Kitae
Oh, Sae Woong
Park, Se Jung
Yu, Eunbi
Yoo, Ju Ah.
Park, See-Hyoung
Kim, Hyeyoun
Yang, Seyoung
Park, Jung Yoen
Cho, Jae Youl
Kim, Youn-Jung
Lee, Jongsung
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Although blue light has been reported to affect skin cells negatively, little is known about its action mechanisms in skin cells.
Therefore, we investigated the role of the transient receptor potential vanilloid 1 (TRPV1) in blue light-induced effects on human keratinocytes and its underlying mechanisms.
Blue light decreased cell proliferation and upregulated TRPV1 expression.
Blue light also suppressed the epidermal growth factor receptor- (EGFR-) mediated signaling pathway by reducing the protein levels of EGFR and suppressing the EGFR/PI3K/AKT/GSK3β/FoxO3a pathway.
The blue light-induced effect in cell proliferation was reversed by TRPV1 siRNA, but not capsazepine, a TRPV1-specific antagonist.
In addition, blue light irradiation increased the production of reactive oxygen species (ROS) and tumor necrosis factor-α (TNF-α).
Blue light irradiation also increased both phosphorylation levels of TRPV1 and calcium influx.
The blue light-induced increase in production of ROS and TNF-α was reversed by capsazepine.
Furthermore, the blue light-induced increase in production of TNF-α was attenuated by SP600125 or PDTC.
These findings show that blue light regulates cell survival and production of ROS and TNF-α; its effects are mediated via TRPV1.
Specifically, the effects of blue light on cell proliferation are mediated by upregulating TRPV1, a negative regulator of EGFR-FoxO3a signaling.
Blue light-induced production of ROS and TNF-α is also mediated through increased calcium influx via TRPV1 activation.
American Psychological Association (APA)
Yoo, Ju Ah.& Yu, Eunbi& Park, See-Hyoung& Oh, Sae Woong& Kwon, Kitae& Park, Se Jung…[et al.]. 2020. Blue Light Irradiation Induces Human Keratinocyte Cell Damage via Transient Receptor Potential Vanilloid 1 (TRPV1) Regulation. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205833
Modern Language Association (MLA)
Yoo, Ju Ah.…[et al.]. Blue Light Irradiation Induces Human Keratinocyte Cell Damage via Transient Receptor Potential Vanilloid 1 (TRPV1) Regulation. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1205833
American Medical Association (AMA)
Yoo, Ju Ah.& Yu, Eunbi& Park, See-Hyoung& Oh, Sae Woong& Kwon, Kitae& Park, Se Jung…[et al.]. Blue Light Irradiation Induces Human Keratinocyte Cell Damage via Transient Receptor Potential Vanilloid 1 (TRPV1) Regulation. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205833