TBHQ-Overview of Multiple Mechanisms against Oxidative Stress for Attenuating Methamphetamine-Induced Neurotoxicity
Joint Authors
Liu, Lian
Zhao, Yuan-Ling
Wang, Yun
Zhao, Wei
Liu, Ming
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Methamphetamine is a derivative of amphetamines, a highly addictive central stimulant with multiple systemic toxicity including the brain, heart, liver, lung, and spleen.
It has adverse effects such as apoptosis and breakdown of the blood-brain barrier.
Methamphetamine is a fatal and toxic chemical substance, and its lethal mechanism has been widely studied in recent years.
The possible mechanism is that methamphetamine can cause cardiotoxicity and neurotoxicity mainly by inducing oxidative stress so as to generate heat, eliminate people’s hunger and thirst, and maintain a state of excitement so that people can continue to exercise.
According to many research, there is no doubt that methamphetamine triggers neurotoxicity by inducing reactive oxygen species (ROS) production and redox imbalance.
This review summarized the mechanisms of methamphetamine-induced neurotoxicity including apoptosis and blood-brain barrier breakdown through oxidative stress and analyzed several possible antioxidative mechanisms of tert-butylhydroquinone (TBHQ) which is a kind of food additive with antioxidative effects.
As a nuclear factor E2-related factor 2 (Nrf2) agonist, TBHQ may inhibit neurotoxicity caused by oxidative stress through the following three mechanisms: the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system, the astrocytes activation, and the glutathione pathway.
The mechanism about methamphetamine’s toxic effects and its antioxidative therapeutic drugs would become a research hotspot in this field and has very important research significance.
American Psychological Association (APA)
Zhao, Yuan-Ling& Zhao, Wei& Liu, Ming& Liu, Lian& Wang, Yun. 2020. TBHQ-Overview of Multiple Mechanisms against Oxidative Stress for Attenuating Methamphetamine-Induced Neurotoxicity. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205836
Modern Language Association (MLA)
Zhao, Yuan-Ling…[et al.]. TBHQ-Overview of Multiple Mechanisms against Oxidative Stress for Attenuating Methamphetamine-Induced Neurotoxicity. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1205836
American Medical Association (AMA)
Zhao, Yuan-Ling& Zhao, Wei& Liu, Ming& Liu, Lian& Wang, Yun. TBHQ-Overview of Multiple Mechanisms against Oxidative Stress for Attenuating Methamphetamine-Induced Neurotoxicity. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205836
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205836