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4-tert-Octylphenol Exposure Disrupts Brain Development and Subsequent Motor, Cognition, Social, and Behavioral Functions
Joint Authors
Tran, Dinh Nam
Jung, Eui-Man
Yoo, Yeong-Min
Jeung, Eui-Bae
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-19
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The endocrine-disrupting chemical 4-tert-octylphenol (OP) is a widespread estrogenic chemical used in consumer products such as epoxy resins and polycarbonate plastic.
However, the effects of OP on brain development are unknown.
The present study examined the effects of OP on neuron and neurobehavioral development in mice.
By using primary cortical neuron cultures, we found that OP-treated showed a decreased length of axons and dendrites and an increased number of primary and secondary dendrites.
OP reduced bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), resulting in a reduction of neuronal progenitor proliferation in offspring mouse brain.
Moreover, OP induced apoptosis in neuronal progenitor cells in offspring mouse brain.
Furthermore, offspring mice from OP-treated dams showed abnormal cognitive, social, and anxiety-like behaviors.
Taken together, these results suggest that perinatal exposure to OP disrupts brain development and behavior in mice.
American Psychological Association (APA)
Tran, Dinh Nam& Jung, Eui-Man& Yoo, Yeong-Min& Jeung, Eui-Bae. 2020. 4-tert-Octylphenol Exposure Disrupts Brain Development and Subsequent Motor, Cognition, Social, and Behavioral Functions. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1205840
Modern Language Association (MLA)
Tran, Dinh Nam…[et al.]. 4-tert-Octylphenol Exposure Disrupts Brain Development and Subsequent Motor, Cognition, Social, and Behavioral Functions. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1205840
American Medical Association (AMA)
Tran, Dinh Nam& Jung, Eui-Man& Yoo, Yeong-Min& Jeung, Eui-Bae. 4-tert-Octylphenol Exposure Disrupts Brain Development and Subsequent Motor, Cognition, Social, and Behavioral Functions. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1205840
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205840