Effect of Anticancer Quinones on Reactive Oxygen Production by Adult Rat Heart Myocytes
Author
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study investigated the effect of anthracycline antibiotics, mitomycin C, and menadione on oxygen consumption and hydrogen peroxide production by intact, beating, rat heart myocytes.
Doxorubicin produced a dose-dependent increase in the rate of cyanide-resistant respiration by beating myocytes.
The anthracycline analogs 4-demethoxydaunorubicin, 4′-epidoxorubicin, 4′-deoxydoxorubicin, and menogaril, as well as the anticancer quinones mitomycin C and menadione, also significantly increased oxygen consumption by cardiac myocytes.
However, 5-iminodaunorubicin (which has a substituted quinone group) and mitoxantrone (which is not easily reduced by flavin dehydrogenases) had no effect on cardiac respiration.
Both catalase (43%) and acetylated cytochrome c (19%) significantly decreased oxygen consumption that had been stimulated by doxorubicin; furthermore, extracellular hydrogen peroxide production was increased from undetectable control levels to 1.30±0.02 nmol/min/107 myocytes (n=4, P<0.01) in the presence of 400 μM doxorubicin.
These experiments suggest that the anthracycline antibiotics and other anticancer quinones stimulate cardiac oxygen radical production in intact heart myocytes; such a free radical cascade could contribute to the cardiac toxicity of these drugs.
American Psychological Association (APA)
Doroshow, James H.. 2020. Effect of Anticancer Quinones on Reactive Oxygen Production by Adult Rat Heart Myocytes. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1205844
Modern Language Association (MLA)
Doroshow, James H.. Effect of Anticancer Quinones on Reactive Oxygen Production by Adult Rat Heart Myocytes. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1205844
American Medical Association (AMA)
Doroshow, James H.. Effect of Anticancer Quinones on Reactive Oxygen Production by Adult Rat Heart Myocytes. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1205844
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205844