![](/images/graphics-bg.png)
Matcha Improves Metabolic Imbalance-Induced Cognitive Dysfunction
Joint Authors
Park, Seon Kyeong
Kang, Jin Yong
Lee, Uk
Kim, Jong Min
Kim, Jong Cheol
Heo, Ho Jin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-29
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
This study was conducted to assess the protective effect of extract of match (EM) on high-fat diet- (HFD-) induced cognitive deficits in male C57BL/6 mice.
It was found that EM improved glucose tolerance status by measuring OGTT and IPGTT with HFD-induced mice.
EM protected behavioral and memory dysfunction in Y-maze, passive avoidance, and Morris water maze tests.
Consumption of EM reduced fat mass, dyslipidemia, and inflammation in adipose tissue.
Also, EM ameliorated hepatic and cerebral antioxidant systems.
EM improved the cerebral cholinergic system by regulating ACh contents and expression of AChE and ChAT.
Also, EM restored mitochondrial function in liver and brain tissue.
EM attenuated hepatic inflammatory effect, lipid synthesis, and cholesterol metabolism by regulating the protein expression of TNF-α, TNFR1, p-IRS-1, p-JNK, IL-1β, iNOS, COX-2, HMGCR, PPARγ, and FAS.
Finally, EM regulated cognitive function and neuroinflammation in the whole brain, hippocampus, and cerebral cortex by regulating the protein expression of p-JNK, p-Akt, p-tau, Aβ, BDNF, IDE, COX-2, and IL-1β.
These findings suggest that EM might be a potential source of functional food to improve metabolic disorder-associated cognitive dysfunction.
American Psychological Association (APA)
Kim, Jong Min& Lee, Uk& Kang, Jin Yong& Park, Seon Kyeong& Kim, Jong Cheol& Heo, Ho Jin. 2020. Matcha Improves Metabolic Imbalance-Induced Cognitive Dysfunction. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1205860
Modern Language Association (MLA)
Kim, Jong Min…[et al.]. Matcha Improves Metabolic Imbalance-Induced Cognitive Dysfunction. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-19.
https://search.emarefa.net/detail/BIM-1205860
American Medical Association (AMA)
Kim, Jong Min& Lee, Uk& Kang, Jin Yong& Park, Seon Kyeong& Kim, Jong Cheol& Heo, Ho Jin. Matcha Improves Metabolic Imbalance-Induced Cognitive Dysfunction. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1205860
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205860