The Protective Role of Probiotics against Colorectal Cancer
Joint Authors
Hu, Chao
Liu, Gang
Ding, Sujuan
Fang, Jun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide and a major global public health problem.
With the rapid development of the economy, the incidence of CRC has increased linearly.
Accumulating evidence indicates that changes in the gut microenvironment, such as undesirable changes in the microbiota composition, provide favorable conditions for intestinal inflammation and shaping the tumor growth environment, whereas administration of certain probiotics can reverse this situation to a certain extent.
This review summarizes the roles of probiotics in the regulation of CRC, such as enhancing the immune barrier, regulating the intestinal immune state, inhibiting pathogenic enzyme activity, regulating CRC cell proliferation and apoptosis, regulating redox homeostasis, and reprograming intestinal microbial composition.
Abundant studies have provided a theoretical foundation for the roles of probiotics in CRC prevention and treatment, but their mechanisms of action remain to be investigated, and further clinical trials are warranted for the application of probiotics in the target population.
American Psychological Association (APA)
Ding, Sujuan& Hu, Chao& Fang, Jun& Liu, Gang. 2020. The Protective Role of Probiotics against Colorectal Cancer. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205867
Modern Language Association (MLA)
Ding, Sujuan…[et al.]. The Protective Role of Probiotics against Colorectal Cancer. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1205867
American Medical Association (AMA)
Ding, Sujuan& Hu, Chao& Fang, Jun& Liu, Gang. The Protective Role of Probiotics against Colorectal Cancer. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205867
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205867