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LKB1AMPK Pathway and Drug Response in Cancer: A Therapeutic Perspective
Joint Authors
Indraccolo, S.
Ciccarese, Francesco
Zulato, Elisabetta
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-31
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Inactivating mutations of the tumor suppressor gene Liver Kinase B1 (LKB1) are frequently detected in non-small-cell lung cancer (NSCLC) and cervical carcinoma.
Moreover, LKB1 expression is epigenetically regulated in several tumor types.
LKB1 has an established function in the control of cell metabolism and oxidative stress.
Clinical and preclinical studies support a role of LKB1 as a central modifier of cellular response to different stress-inducing drugs, suggesting LKB1 pathway as a highly promising therapeutic target.
Loss of LKB1-AMPK signaling confers sensitivity to energy depletion and to redox homeostasis impairment and has been associated with an improved outcome in advanced NSCLC patients treated with chemotherapy.
In this review, we provide an overview of the interplay between LKB1 and its downstream targets in cancer and focus on potential therapeutic strategies whose outcome could depend from LKB1.
American Psychological Association (APA)
Ciccarese, Francesco& Zulato, Elisabetta& Indraccolo, S.. 2019. LKB1AMPK Pathway and Drug Response in Cancer: A Therapeutic Perspective. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1205870
Modern Language Association (MLA)
Ciccarese, Francesco…[et al.]. LKB1AMPK Pathway and Drug Response in Cancer: A Therapeutic Perspective. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1205870
American Medical Association (AMA)
Ciccarese, Francesco& Zulato, Elisabetta& Indraccolo, S.. LKB1AMPK Pathway and Drug Response in Cancer: A Therapeutic Perspective. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1205870
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205870