Pigment Epithelium-Derived Factor as a Possible Treatment Agent for Choroidal Neovascularization
Author
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Choroidal neovascularization (CNV) is a sight-threatening disease and is characterized by the formation of pathological neovascularization in the choroid which extends into the subretinal space.
Exudative age-related macular degeneration (AMD) is the formation of CNV in the macular area which leads to irreversible blindness.
Continuous leakage and hemorrhage of the CNV lesion may eventually result in scarring or later fibrosis, which could result in photoreceptor cell atrophy.
The current strategy for treating CNV is the use of antivascular endothelial growth factor (VEGF) agents.
Many studies have demonstrated the efficacy of intravitreal anti-VEGF therapy.
Other studies have also reported the side effects of single anti-VEGF treatment.
And long-term inhibition of a single system may result in collateral damage to other visual elements.
Pigment epithelium-derived factor (PEDF) is a 50 kDa protein that was first isolated from the conditioned medium of human RPE cells.
PEDF has both antiangiogenesis and neuroprotective functions for photoreceptor cells.
It may be a potential ocular antiangiogenic agent.
This review outlines the distribution of PEDF in the eye, the mechanism of antiangiogenesis, the protective effect on the retina, and the relationship between PEDF and VEGF.
American Psychological Association (APA)
Xi, Lei. 2020. Pigment Epithelium-Derived Factor as a Possible Treatment Agent for Choroidal Neovascularization. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205905
Modern Language Association (MLA)
Xi, Lei. Pigment Epithelium-Derived Factor as a Possible Treatment Agent for Choroidal Neovascularization. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1205905
American Medical Association (AMA)
Xi, Lei. Pigment Epithelium-Derived Factor as a Possible Treatment Agent for Choroidal Neovascularization. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205905
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205905