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Baicalin Represses CEBPβ via Its Antioxidative Effect in Parkinson’s Disease
Joint Authors
Lei, Kecheng
Shen, Yijue
He, Yijing
Zhang, Liwen
Zhang, Jingxing
Tong, Weifang
Xu, Yichun
Jin, Lingjing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-22
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Parkinson’s disease (PD) is a neurodegenerative disease characterized by the gradual loss of dopaminergic (DA) neurons in the substantia nigra (SN) and the formation of intracellular Lewy bodies (LB) in the brain, which aggregates α-synuclein (α-Syn) as the main component.
The interest of flavonoids as potential neuroprotective agents is increasing due to its high efficiency and low side effects.
Baicalin is one of the flavonoid compounds, which is a predominant flavonoid isolated from Scutellaria baicalensis Georgi.
However, the key molecular mechanism by which Baicalin can prevent the PD pathogenesis remains unclear.
In this study, we used bioinformatic assessment including Gene Ontology (GO) to elucidate the correlation between oxidative stress and PD pathogenesis.
RNA-Seq methods were used to examine the global expression profiles of noncoding RNAs and found that C/EBPβ expression was upregulated in PD patients compared with healthy controls.
Interestingly, Baicalin could protect DA neurons against reactive oxygen species (ROS) and decreased C/EBPβ and α-synuclein expression in pLVX-Tet3G-α-synuclein SH-SY5Y cells.
In a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced PD mouse model, the results revealed that treatment with Baicalin improved the PD model’s behavioral performance and reduced dopaminergic neuron loss in the substantia nigra, associated with the inactivation of proinflammatory cytokines and oxidative stress.
Hence, our study supported that Baicalin repressed C/EBPβ via redox homeostasis, which may be an effective potential treatment for PD.
American Psychological Association (APA)
Lei, Kecheng& Shen, Yijue& He, Yijing& Zhang, Liwen& Zhang, Jingxing& Tong, Weifang…[et al.]. 2020. Baicalin Represses CEBPβ via Its Antioxidative Effect in Parkinson’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205913
Modern Language Association (MLA)
Lei, Kecheng…[et al.]. Baicalin Represses CEBPβ via Its Antioxidative Effect in Parkinson’s Disease. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1205913
American Medical Association (AMA)
Lei, Kecheng& Shen, Yijue& He, Yijing& Zhang, Liwen& Zhang, Jingxing& Tong, Weifang…[et al.]. Baicalin Represses CEBPβ via Its Antioxidative Effect in Parkinson’s Disease. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205913
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205913