Biochanin A Mitigates Atherosclerosis by Inhibiting Lipid Accumulation and Inflammatory Response

Joint Authors

Yu, Xiao-Hua
Chen, Jiao-Jiao
Deng, Wen-Yi
Xu, Xiao-Dan
Liu, Qi-Xian
Shi, Meng-Wen
Ren, Kun

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-11-11

Country of Publication

Egypt

No. of Pages

15

Main Subjects

Biology

Abstract EN

Biochanin A (BCA), a dietary isoflavone extracted from red clover and cabbage, has been shown to antagonize hypertension and myocardial ischemia/reperfusion injury.

However, very little is known about its role in atherogenesis.

The aim of this study was to observe the effects of BCA on atherosclerosis and explore the underlying mechanisms.

Our results showed that administration of BCA promoted reverse cholesterol transport (RCT), improved plasma lipid profile, and decreased serum proinflammatory cytokine levels and atherosclerotic lesion area in apoE-/- mice fed a Western diet.

In THP-1 macrophage-derived foam cells, treatment with BCA upregulated ATP-binding cassette (ABC) transporter A1 (ABCA1) and ABCG1 expression and facilitated subsequent cholesterol efflux and diminished intracellular cholesterol contents by activating the peroxisome proliferator-activated receptor γ (PPARγ)/liver X receptor α (LXRα) and PPARγ/heme oxygenase 1 (HO-1) pathways.

BCA also activated these two signaling pathways to inhibit the secretion of proinflammatory cytokines.

Taken together, these findings suggest that BCA is protective against atherosclerosis by inhibiting lipid accumulation and inflammatory response through the PPARγ/LXRα and PPARγ/HO-1 pathways.

BCA may be an attractive drug for the prevention and treatment of atherosclerotic cardiovascular disease.

American Psychological Association (APA)

Yu, Xiao-Hua& Chen, Jiao-Jiao& Deng, Wen-Yi& Xu, Xiao-Dan& Liu, Qi-Xian& Shi, Meng-Wen…[et al.]. 2020. Biochanin A Mitigates Atherosclerosis by Inhibiting Lipid Accumulation and Inflammatory Response. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1205923

Modern Language Association (MLA)

Yu, Xiao-Hua…[et al.]. Biochanin A Mitigates Atherosclerosis by Inhibiting Lipid Accumulation and Inflammatory Response. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1205923

American Medical Association (AMA)

Yu, Xiao-Hua& Chen, Jiao-Jiao& Deng, Wen-Yi& Xu, Xiao-Dan& Liu, Qi-Xian& Shi, Meng-Wen…[et al.]. Biochanin A Mitigates Atherosclerosis by Inhibiting Lipid Accumulation and Inflammatory Response. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1205923

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1205923