Biochanin A Mitigates Atherosclerosis by Inhibiting Lipid Accumulation and Inflammatory Response
Joint Authors
Yu, Xiao-Hua
Chen, Jiao-Jiao
Deng, Wen-Yi
Xu, Xiao-Dan
Liu, Qi-Xian
Shi, Meng-Wen
Ren, Kun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-11
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Biochanin A (BCA), a dietary isoflavone extracted from red clover and cabbage, has been shown to antagonize hypertension and myocardial ischemia/reperfusion injury.
However, very little is known about its role in atherogenesis.
The aim of this study was to observe the effects of BCA on atherosclerosis and explore the underlying mechanisms.
Our results showed that administration of BCA promoted reverse cholesterol transport (RCT), improved plasma lipid profile, and decreased serum proinflammatory cytokine levels and atherosclerotic lesion area in apoE-/- mice fed a Western diet.
In THP-1 macrophage-derived foam cells, treatment with BCA upregulated ATP-binding cassette (ABC) transporter A1 (ABCA1) and ABCG1 expression and facilitated subsequent cholesterol efflux and diminished intracellular cholesterol contents by activating the peroxisome proliferator-activated receptor γ (PPARγ)/liver X receptor α (LXRα) and PPARγ/heme oxygenase 1 (HO-1) pathways.
BCA also activated these two signaling pathways to inhibit the secretion of proinflammatory cytokines.
Taken together, these findings suggest that BCA is protective against atherosclerosis by inhibiting lipid accumulation and inflammatory response through the PPARγ/LXRα and PPARγ/HO-1 pathways.
BCA may be an attractive drug for the prevention and treatment of atherosclerotic cardiovascular disease.
American Psychological Association (APA)
Yu, Xiao-Hua& Chen, Jiao-Jiao& Deng, Wen-Yi& Xu, Xiao-Dan& Liu, Qi-Xian& Shi, Meng-Wen…[et al.]. 2020. Biochanin A Mitigates Atherosclerosis by Inhibiting Lipid Accumulation and Inflammatory Response. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1205923
Modern Language Association (MLA)
Yu, Xiao-Hua…[et al.]. Biochanin A Mitigates Atherosclerosis by Inhibiting Lipid Accumulation and Inflammatory Response. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1205923
American Medical Association (AMA)
Yu, Xiao-Hua& Chen, Jiao-Jiao& Deng, Wen-Yi& Xu, Xiao-Dan& Liu, Qi-Xian& Shi, Meng-Wen…[et al.]. Biochanin A Mitigates Atherosclerosis by Inhibiting Lipid Accumulation and Inflammatory Response. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1205923
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205923