Potential Role of Antioxidants as Adjunctive Therapy in Chagas Disease
Joint Authors
Sánchez-Villamil, Juana P.
Bautista-Niño, Paula K.
Serrano, Norma C.
Rincon, Melvin Y.
Garg, Nisha Jain
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Chagas disease (CD) is one of the most important neglected tropical diseases in the American continent.
Host-derived nitroxidative stress in response to Trypanosoma cruzi infection can induce tissue damage contributing to the progression of Chagas disease.
Antioxidant supplementation has been suggested as adjuvant therapy to current treatment.
In this article, we synthesize and discuss the current evidence regarding the use of antioxidants as adjunctive compounds to fight harmful reactive oxygen species and lower the tissue oxidative damage during progression of chronic Chagas disease.
Several antioxidants evaluated in recent studies have shown potential benefits for the control of oxidative stress in the host’s tissues.
Melatonin, resveratrol, the combination of vitamin C/vitamin E (vitC/vitE) or curcumin/benznidazole, and mitochondria-targeted antioxidants seem to be beneficial in reducing plasma and cardiac levels of lipid peroxidation products.
Nevertheless, further research is needed to validate beneficial effects of antioxidant therapies in Chagas disease.
American Psychological Association (APA)
Sánchez-Villamil, Juana P.& Bautista-Niño, Paula K.& Serrano, Norma C.& Rincon, Melvin Y.& Garg, Nisha Jain. 2020. Potential Role of Antioxidants as Adjunctive Therapy in Chagas Disease. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1205945
Modern Language Association (MLA)
Sánchez-Villamil, Juana P.…[et al.]. Potential Role of Antioxidants as Adjunctive Therapy in Chagas Disease. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1205945
American Medical Association (AMA)
Sánchez-Villamil, Juana P.& Bautista-Niño, Paula K.& Serrano, Norma C.& Rincon, Melvin Y.& Garg, Nisha Jain. Potential Role of Antioxidants as Adjunctive Therapy in Chagas Disease. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1205945
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205945