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Mangiferin Prevents TBHP-Induced Apoptosis and ECM Degradation in Mouse Osteoarthritic Chondrocytes via Restoring Autophagy and Ameliorates Murine Osteoarthritis
Joint Authors
Xiao, Jian
Liu, Yanlong
Li, Yao
Wu, Yaosen
Jiang, Kaixia
Han, Wen
Zhang, Jing
Xie, Lin
Wang, Xiangyang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-15
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Osteoarthritis (OA) is an age-related degenerative disease with complicated pathology involving chondrocyte apoptosis and extracellular matrix (ECM) degradation.
Previous studies have shown that moderate autophagy has a protective effect against apoptosis in chondrocyte.
Mangiferin is a natural polyphenol and exerts multiple pharmacological effects on different diseases in various preclinical studies.
In this study, we investigated the effects of mangiferin on OA and delineated a potential molecular mechanism.
In vitro, mangiferin treatment inhibited the expression of proapoptotic proteins induced by tert-butyl hydroperoxide (TBHP), increased the expression of antiapoptotic Bcl-2, and prevented ECM degradation by inhibiting the production of matrix-degrading enzyme.
Mechanistically, mangiferin enhanced autophagy by activating the AMP-activated protein kinase (AMPK) signaling pathway.
On the contrary, inhibition of autophagy partly abolished the protective effects of mangiferin on antiapoptosis and ECM synthesis in TBHP-treated chondrocyte.
Correspondingly, the protective effect of mangiferin was also found in a mouse OA model.
In conclusion, our results suggested that mangiferin serves as a potentially applicable candidate for treating OA.
American Psychological Association (APA)
Li, Yao& Wu, Yaosen& Jiang, Kaixia& Han, Wen& Zhang, Jing& Xie, Lin…[et al.]. 2019. Mangiferin Prevents TBHP-Induced Apoptosis and ECM Degradation in Mouse Osteoarthritic Chondrocytes via Restoring Autophagy and Ameliorates Murine Osteoarthritis. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1205946
Modern Language Association (MLA)
Li, Yao…[et al.]. Mangiferin Prevents TBHP-Induced Apoptosis and ECM Degradation in Mouse Osteoarthritic Chondrocytes via Restoring Autophagy and Ameliorates Murine Osteoarthritis. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-1205946
American Medical Association (AMA)
Li, Yao& Wu, Yaosen& Jiang, Kaixia& Han, Wen& Zhang, Jing& Xie, Lin…[et al.]. Mangiferin Prevents TBHP-Induced Apoptosis and ECM Degradation in Mouse Osteoarthritic Chondrocytes via Restoring Autophagy and Ameliorates Murine Osteoarthritis. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1205946
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205946