Increased Expression of BIRC2, BIRC3, and BIRC5 from the IAP Family in Mesenchymal Stem Cells of the Umbilical Cord Wharton’s Jelly (WJSC) in Younger Women Giving Birth Naturally
Joint Authors
Rahnama, Mansur
Kocki, Janusz
Gil-Kulik, Paulina
Chomik, Piotr
Krzyżanowski, Arkadiusz
Kwaśniewska, Anna
Świstowska, Małgorzata
Kondracka, Adrianna
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The knowledge of factors affecting the viability as well as proliferation and therapeutic potential of perinatal stem cells is of great importance for the decisions concerning their collection, multiplication, and storing.
The aim of this work is to evaluate the expression of the BIRC2, BIRC3, and BIRC5 genes at the level of transcription in mesenchymal stem cells derived from the umbilical cord Wharton’s jelly.
The study examined the relationship between the expression level of the studied genes and selected biophysical parameters of umbilical blood: pH, pCO2, pO2, and cHCO3.
Moreover, the relationship between the pregnant age, the type of delivery (natural delivery or cesarean section), and the level of expression of the BIRC2, BIRC3, and BIRC5 genes was assessed.
The research was carried out on mesenchymal stem cells derived from the umbilical cord Wharton’s jelly (WJSC) taken from 55 women immediately after delivery.
Expression of the examined genes was assessed with the qPCR method using commercially available reagent kits.
On the basis of the conducted research, it was demonstrated that WJSCs collected from younger women giving birth naturally, and in the acidic environment of the umbilical cord blood, are characterized by a higher expression of the BIRC2, BIRC3, and BIRC5 genes.
It was shown that the expression of the BIRC2 and BIRC3 genes in Wharton’s jelly mesenchymal stem cells declines with the mother’s age.
Our research suggests that stem cells collected from younger women giving birth naturally can be more resistant to apoptosis and show a more stem cell-like character, which can increase their therapeutic potential and clinical utility, but this conclusion needs to be approved in the next studies.
American Psychological Association (APA)
Gil-Kulik, Paulina& Świstowska, Małgorzata& Kondracka, Adrianna& Chomik, Piotr& Krzyżanowski, Arkadiusz& Kwaśniewska, Anna…[et al.]. 2020. Increased Expression of BIRC2, BIRC3, and BIRC5 from the IAP Family in Mesenchymal Stem Cells of the Umbilical Cord Wharton’s Jelly (WJSC) in Younger Women Giving Birth Naturally. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205948
Modern Language Association (MLA)
Gil-Kulik, Paulina…[et al.]. Increased Expression of BIRC2, BIRC3, and BIRC5 from the IAP Family in Mesenchymal Stem Cells of the Umbilical Cord Wharton’s Jelly (WJSC) in Younger Women Giving Birth Naturally. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1205948
American Medical Association (AMA)
Gil-Kulik, Paulina& Świstowska, Małgorzata& Kondracka, Adrianna& Chomik, Piotr& Krzyżanowski, Arkadiusz& Kwaśniewska, Anna…[et al.]. Increased Expression of BIRC2, BIRC3, and BIRC5 from the IAP Family in Mesenchymal Stem Cells of the Umbilical Cord Wharton’s Jelly (WJSC) in Younger Women Giving Birth Naturally. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205948
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205948