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Gentiopicroside, a Secoiridoid Glycoside from Gentiana rigescens Franch, Extends the Lifespan of Yeast via Inducing Mitophagy and Antioxidative Stress
Joint Authors
Matsuura, Akira
Xiang, Lan
Qi, Jianhua
Cheng, Lihong
Liu, Qian
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Gentiopicroside (GPS), an antiaging secoiridoid glycoside, was isolated from Gentiana rigescens Franch, a traditional Chinese medicine.
It prolonged the replicative and chronological lifespans of yeast.
Autophagy, especially mitophagy, and antioxidative stress were examined to clarify the mechanism of action of this compound.
The free green fluorescent protein (GFP) signal from the cleavage of GFP-Atg8 and the colocation signal of MitoTracker Red CMXRos and GFP were increased upon the treatment of GPS.
The free GFP in the cytoplasm and free GFP and ubiquitin of mitochondria were significantly increased at the protein levels in the GPS-treated group.
GPS increased the expression of an essential autophagy gene, ATG32 gene, but failed to extend the replicative and chronological lifespans of ATG32 yeast mutants.
GPS increased the survival rate of yeast under oxidative stress condition; enhanced the activities of catalase, superoxide dismutase, and glutathione peroxidase; and decreased the levels of reactive oxygen species and malondialdehyde.
The replicative lifespans of Δsod1, Δsod2, Δuth1, and Δskn7 were not affected by GPS.
These results indicated that autophagy, especially mitophagy, and antioxidative stress are involved in the antiaging effect of GPS.
American Psychological Association (APA)
Liu, Qian& Cheng, Lihong& Matsuura, Akira& Xiang, Lan& Qi, Jianhua. 2020. Gentiopicroside, a Secoiridoid Glycoside from Gentiana rigescens Franch, Extends the Lifespan of Yeast via Inducing Mitophagy and Antioxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205961
Modern Language Association (MLA)
Liu, Qian…[et al.]. Gentiopicroside, a Secoiridoid Glycoside from Gentiana rigescens Franch, Extends the Lifespan of Yeast via Inducing Mitophagy and Antioxidative Stress. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1205961
American Medical Association (AMA)
Liu, Qian& Cheng, Lihong& Matsuura, Akira& Xiang, Lan& Qi, Jianhua. Gentiopicroside, a Secoiridoid Glycoside from Gentiana rigescens Franch, Extends the Lifespan of Yeast via Inducing Mitophagy and Antioxidative Stress. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205961
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205961