Dipeptidyl Peptidase 4 Inhibition Ameliorates Chronic Kidney Disease in a Model of Salt-Dependent Hypertension
Joint Authors
Berrino, L.
De Angelis, A.
Urbanek, Konrad
Cappetta, Donato
Esposito, Grazia
Naviglio, Silvio
Sapio, Luigi
D’Amario, Domenico
Crea, Filippo
Rossi, Francesco
Ciuffreda, Loreta Pia
Cozzolino, Anna
Scavone, Cristina
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Cardiovascular diseases frequently coexist with chronic kidney disease that constitutes a major determinant of outcome in patients with heart failure.
Dysfunction of both organs is related to chronic inflammation, endothelial dysfunction, oxidative stress, and fibrosis.
Widespread expression of serine protease DPP4 that degrades varieties of substrates suggests its involvement in numerous physiological processes.
In this study, we tested the effects of selective DPP4 inhibition on the progression of renal disease in a nondiabetic model of hypertensive heart disease using Dahl salt-sensitive rats.
Chronic DPP4 inhibition positively affected renal function with a significant reduction in albuminuria and serum creatinine.
DPP4 inhibition attenuated the inflammatory component by reducing the expression of NF-κB, TNFα, IL-1β, IL-6, and MCP-1.
Kidney macrophages expressed GLP-1R, and DPP4 inhibition promoted macrophage polarization toward the anti-inflammatory M2 phenotype.
Finally, high degrees of NADPH oxidase 4 expression and oxidation of nucleic acids, lipids, and proteins were reduced upon DPP4 inhibition.
Our study provides evidence of renoprotection by DPP4 inhibition in a nondiabetic hypertension-induced model of chronic cardiorenal syndrome, indicating that DPP4 pathway remains a valid object to study in the context of chronic multiorgan diseases.
American Psychological Association (APA)
Cappetta, Donato& Ciuffreda, Loreta Pia& Cozzolino, Anna& Esposito, Grazia& Scavone, Cristina& Sapio, Luigi…[et al.]. 2019. Dipeptidyl Peptidase 4 Inhibition Ameliorates Chronic Kidney Disease in a Model of Salt-Dependent Hypertension. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1205969
Modern Language Association (MLA)
Cappetta, Donato…[et al.]. Dipeptidyl Peptidase 4 Inhibition Ameliorates Chronic Kidney Disease in a Model of Salt-Dependent Hypertension. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1205969
American Medical Association (AMA)
Cappetta, Donato& Ciuffreda, Loreta Pia& Cozzolino, Anna& Esposito, Grazia& Scavone, Cristina& Sapio, Luigi…[et al.]. Dipeptidyl Peptidase 4 Inhibition Ameliorates Chronic Kidney Disease in a Model of Salt-Dependent Hypertension. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1205969
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205969