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Blood Oxidative Stress Marker Aberrations in Patients with Huntington’s Disease: A Meta-Analysis Study
Joint Authors
Cheng, Yong
Tang, Quan
Shi, Xiao-Jie
Liu, Hua
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Huntington’s disease (HD) is a hereditary autosomal dominant neurodegenerative disease.
Although studies have shown that blood oxidative stress markers are dysregulated in HD patients, clinical data on the blood oxidative stress markers of HD patients is inconsistent.
To better understand the pathogenesis of HD, we performed a systematic review and meta-analysis of blood oxidative stress markers in HD patients and healthy control (HC) subjects.
A database search from PubMed and Web of Science identified 12 studies with 375 HD patients and 447 HC subjects in this meta-analysis.
A random-effects meta-analysis showed that blood lipid peroxidation products (Hedges’ g=0.883, 95%CI=0.637 to 1.130, p<0.001), 8-hydroxyguanosine (Hedges’ g=1.727, 95%CI=0.489 to 2.965, p=0.006) levels, and the activity of glutathione peroxidase (Hedges’ g=2.026, 95%CI=0.570 to 3.482, p=0.006) were significantly increased in HD patients compared to controls.
In contrast, reduced glutathione levels were lower in HD patients than in controls (Hedges’ g=−0.611, 95%CI=−1.016 to−0.207, p=0.003).
However, blood superoxide dismutase, cholesterol, high-density lipoproteins, low-density lipoproteins, and triglycerides did not show significant differences between cases and controls.
Taken together, this study clarified the associations between blood oxidative stress markers and HD, supporting the clinical evidence that HD is accompanied by increased oxidative stress.
American Psychological Association (APA)
Tang, Quan& Liu, Hua& Shi, Xiao-Jie& Cheng, Yong. 2020. Blood Oxidative Stress Marker Aberrations in Patients with Huntington’s Disease: A Meta-Analysis Study. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205975
Modern Language Association (MLA)
Tang, Quan…[et al.]. Blood Oxidative Stress Marker Aberrations in Patients with Huntington’s Disease: A Meta-Analysis Study. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1205975
American Medical Association (AMA)
Tang, Quan& Liu, Hua& Shi, Xiao-Jie& Cheng, Yong. Blood Oxidative Stress Marker Aberrations in Patients with Huntington’s Disease: A Meta-Analysis Study. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205975
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205975