Electroacupuncture Pretreatment Attenuates Intestinal Injury after Autogenous Orthotopic Liver Transplantation in Rats via the JAKSTAT Pathway
Joint Authors
Jia, Lili
Yu, Hongli
Weng, Yiqi
Yu, Wenli
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Liver transplantation induces self-injury and affects remote organs, such as the lung, kidney, and intestine.
Postoperative intestinal dysfunction has been associated with prolonged hospitalization and affects a patient’s health and quality of life.
Electroacupuncture (EA) has been proven effective in multiple organ protection.
However, the potential mechanism underlying the protective effects of EA on intestinal injury after liver transplantation remains unclear.
Methods.
After establishing an autogenous orthotopic liver transplantation (AOLT) model, we studied the effects of EA pretreatment on intestinal injury after AOLT.
We used the JAK2-specific inhibitor AG490 to explore the underlying mechanism.
Histological analysis and apoptosis assays were used to evaluate intestinal injury.
Oxidative stress index and inflammatory response were also measured after AOLT.
Furthermore, we detected the phosphorylation levels of JAK2, STAT1, and STAT3 by Western blot.
Results.
We found that pretreatment with EA alleviated intestinal injury after AOLT, as shown by HE staining and TUNEL methods.
EA pretreatment inhibited the expressions of p-JAK2, p-STAT1, and p-STAT3 in the intestines after AOLT.
Upon treatment with JAK2-specific inhibitor AG490, intestinal injury was balanced.
Conclusion.
The data indicated EA pretreatment alleviated intestinal injury after AOLT by inhibiting the JAK/STAT signaling pathway.
These results provide basic evidence to support the potential therapeutic efficacy of EA.
American Psychological Association (APA)
Jia, Lili& Yu, Wenli& Yu, Hongli& Weng, Yiqi. 2020. Electroacupuncture Pretreatment Attenuates Intestinal Injury after Autogenous Orthotopic Liver Transplantation in Rats via the JAKSTAT Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205977
Modern Language Association (MLA)
Jia, Lili…[et al.]. Electroacupuncture Pretreatment Attenuates Intestinal Injury after Autogenous Orthotopic Liver Transplantation in Rats via the JAKSTAT Pathway. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1205977
American Medical Association (AMA)
Jia, Lili& Yu, Wenli& Yu, Hongli& Weng, Yiqi. Electroacupuncture Pretreatment Attenuates Intestinal Injury after Autogenous Orthotopic Liver Transplantation in Rats via the JAKSTAT Pathway. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205977