Nitric Oxide Stimulates Acute Pancreatitis Pain via Activating the NF-κB Signaling Pathway and Inhibiting the Kappa Opioid Receptor
Joint Authors
Shen, Xin
Ma, Qingyong
Qin, Tao
Qian, Weikun
Xiao, Ying
Xue, Mengwen
Han, Liang
Li, Jie
Ma, Jiguang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Pain is the most important clinical feature of acute pancreatitis (AP); however, its specific mechanism is currently unclear.
In this study, we showed that AP caused an increase in nitric oxide (NO) secretion, activated the NF-κB pathway in the dorsal root ganglia (DRGs), and caused pain.
We established an AP model in vivo and tested the expression of NO, the kappa opioid receptor (KOR), and pain factors.
We showed that NO in AP was significantly elevated and increased the expression of pain factors.
Next, by treating DRGs in vitro, it was found that NO activated the NF-κB pathway; conversely, NF-κB had no effect on NO.
Moreover, inhibition of NF-κB promoted the KOR, whereas NF-κB did not change after KOR activation.
Finally, behavioral experiments showed that a NO donor increased the pain behavior of mice, while a NO scavenger, NF-κB inhibitor, or KOR agonist attenuated the pain response in mice.
These results suggest that iNOS/NO/NF-κB/KOR may be a key mechanism of pain in AP, providing a theoretical basis for the use of peripheral-restricted KOR agonists for pain treatment in AP.
American Psychological Association (APA)
Xue, Mengwen& Han, Liang& Qian, Weikun& Li, Jie& Qin, Tao& Xiao, Ying…[et al.]. 2020. Nitric Oxide Stimulates Acute Pancreatitis Pain via Activating the NF-κB Signaling Pathway and Inhibiting the Kappa Opioid Receptor. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1205990
Modern Language Association (MLA)
Xue, Mengwen…[et al.]. Nitric Oxide Stimulates Acute Pancreatitis Pain via Activating the NF-κB Signaling Pathway and Inhibiting the Kappa Opioid Receptor. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1205990
American Medical Association (AMA)
Xue, Mengwen& Han, Liang& Qian, Weikun& Li, Jie& Qin, Tao& Xiao, Ying…[et al.]. Nitric Oxide Stimulates Acute Pancreatitis Pain via Activating the NF-κB Signaling Pathway and Inhibiting the Kappa Opioid Receptor. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1205990
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205990