Fenofibrate Improved Interstitial Fibrosis of Renal Allograft through Inhibited Epithelial-Mesenchymal Transition Induced by Oxidative Stress
Joint Authors
Pang, Lei
Wang, Yishu
Zhang, Yanghe
Lin, Jiahui
Zhou, Honglan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The best treatment for end-stage renal disease is renal transplantation.
However, it is often difficult to maintain a renal allograft healthy for a long time following transplantation.
Interstitial fibrosis and tubular atrophy (IF/TA) are significant histopathologic characteristics of a compromised renal allograft.
There is no effective therapy to improve renal allograft function once IF/TA sets in.
Although there are many underlying factors that can induce IF/TA, the pathogenesis of IF/TA has not been fully elucidated.
It has been found that epithelial-mesenchymal transition (EMT) significantly contributes to the development of IF/TA.
Oxidative stress is one of the main causes that induce EMT in renal allografts.
In this study, we have used H2O2 to induce oxidative stress in renal tubular epithelial cells (NRK-52e) of rats.
We also pretreated NRK-52e cells with an antioxidant (N-acetyl L-cysteine (NAC)) 1 h prior to the treatment with H2O2.
Furthermore, we used fenofibrate (a peroxisome proliferator-activated receptor α agonist) to treat NRK-52e cells and a renal transplant rat model.
Our results reveal that oxidative stress induces EMT in NRK-52e cells, and pretreatment with NAC can suppress EMT in these cells.
Moreover, fenofibrate suppresses fibrosis by ameliorating oxidative stress-induced EMT in a rat model.
Thus, fenofibrate may effectively prevent the development of fibrosis in renal allograft and improve the outcome.
American Psychological Association (APA)
Wang, Yishu& Pang, Lei& Zhang, Yanghe& Lin, Jiahui& Zhou, Honglan. 2019. Fenofibrate Improved Interstitial Fibrosis of Renal Allograft through Inhibited Epithelial-Mesenchymal Transition Induced by Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1205994
Modern Language Association (MLA)
Wang, Yishu…[et al.]. Fenofibrate Improved Interstitial Fibrosis of Renal Allograft through Inhibited Epithelial-Mesenchymal Transition Induced by Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1205994
American Medical Association (AMA)
Wang, Yishu& Pang, Lei& Zhang, Yanghe& Lin, Jiahui& Zhou, Honglan. Fenofibrate Improved Interstitial Fibrosis of Renal Allograft through Inhibited Epithelial-Mesenchymal Transition Induced by Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1205994
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205994