Leukocyte Telomere Length Independently Predicts 3-Year Diabetes Risk in a Longitudinal Study of Chinese Population
Joint Authors
Ping, Fan
Li, Yu-xiu
Liu, Yiwen
Xu, Lingling
He, Shuli
Li, Pingping
Ma, Chunxiao
Zhang, Huabing
Li, Wei
Ma, Chifa
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cellular aging markers, including telomere length and mitochondrial function, as well as oxidative stress and inflammation markers influence each other and form a complex network, which is affected in diabetes.
However, it remains unknown whether these markers could independently predict future diabetes after adjustment for their mutual effects.
We conducted a 3-year longitudinal study in a Chinese cohort that comprised 108 nondiabetic individuals at baseline.
The 2-hour 75 g oral glucose tolerance tests were performed at baseline and at 3-year follow-up.
At baseline, leukocyte telomere length (LTL) and mitochondrial DNA copy number (mtDNAcn) in leukocytes were determined using the polymerase chain reaction method.
Tumor necrosis factor (TNF-α), interleukin-6, 8-hydroxy-2-deoxyguanosine levels, and superoxide dismutase (SOD) activity were measured by the enzyme-linked immunosorbent assay.
Participants who developed diabetes at the 3-year follow-up (n=28) had shorter LTL and higher levels of TNF-α and SOD activity at baseline.
Baseline LTL was found to be independently associated with the development of diabetes at the 3-year follow-up after the adjustment for mtDNAcn, markers of oxidative stress and inflammation, and conventional diabetes risk factors.
Our findings suggest that LTL is an independent predictor for 3-year diabetes risk, which might inform timely prevention and treatment of diabetes.
Telomere shortening might be involved in the pathogenesis of diabetes independently of conventional diabetes risk factors, mtDNAcn, or oxidative stress and inflammation pathways.
American Psychological Association (APA)
Liu, Yiwen& Ma, Chifa& Li, Pingping& Ma, Chunxiao& He, Shuli& Ping, Fan…[et al.]. 2020. Leukocyte Telomere Length Independently Predicts 3-Year Diabetes Risk in a Longitudinal Study of Chinese Population. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1206000
Modern Language Association (MLA)
Liu, Yiwen…[et al.]. Leukocyte Telomere Length Independently Predicts 3-Year Diabetes Risk in a Longitudinal Study of Chinese Population. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1206000
American Medical Association (AMA)
Liu, Yiwen& Ma, Chifa& Li, Pingping& Ma, Chunxiao& He, Shuli& Ping, Fan…[et al.]. Leukocyte Telomere Length Independently Predicts 3-Year Diabetes Risk in a Longitudinal Study of Chinese Population. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1206000
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206000