Role of Endoplasmic Reticulum Stress in Atherosclerosis and Its Potential as a Therapeutic Target
Joint Authors
Wu, Min
Li, Xiaoya
Zhao, Ran
Yang, Shengjie
Zhao, Yixi
Liu, Longtao
Wang, Songzi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-09
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Endoplasmic reticulum (ER) stress is closely associated with atherosclerosis and related cardiovascular diseases (CVDs).
It occurs due to various pathological factors that interfere with ER homeostasis, resulting in the accumulation of unfolded or misfolded proteins in the ER lumen, thereby causing ER dysfunction.
Here, we discuss the role of ER stress in different types of cells in atherosclerotic lesions.
This discussion includes the activation of apoptotic and inflammatory pathways induced by prolonged ER stress, especially in advanced lesional macrophages and endothelial cells (ECs), as well as common atherosclerosis-related ER stressors in different lesional cells, which all contribute to the clinical progression of atherosclerosis.
In view of the important role of ER stress and the unfolded protein response (UPR) signaling pathways in atherosclerosis and CVDs, targeting these processes to reduce ER stress may be a novel therapeutic strategy.
American Psychological Association (APA)
Yang, Shengjie& Wu, Min& Li, Xiaoya& Zhao, Ran& Zhao, Yixi& Liu, Longtao…[et al.]. 2020. Role of Endoplasmic Reticulum Stress in Atherosclerosis and Its Potential as a Therapeutic Target. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1206010
Modern Language Association (MLA)
Yang, Shengjie…[et al.]. Role of Endoplasmic Reticulum Stress in Atherosclerosis and Its Potential as a Therapeutic Target. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1206010
American Medical Association (AMA)
Yang, Shengjie& Wu, Min& Li, Xiaoya& Zhao, Ran& Zhao, Yixi& Liu, Longtao…[et al.]. Role of Endoplasmic Reticulum Stress in Atherosclerosis and Its Potential as a Therapeutic Target. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1206010
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206010