Monoamine Oxidase-Related Vascular Oxidative Stress in Diseases Associated with Inflammatory Burden
Joint Authors
Duicu, Oana M.
Sturza, Adrian
Muntean, Danina M.
Popoiu, Călin M.
Ionică, Mihaela
Olariu, Sorin
Boia, Eugen S.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Monoamine oxidases (MAO) with 2 isoforms, A and B, located at the outer mitochondrial membrane are flavoenzyme membranes with a major role in the metabolism of monoaminergic neurotransmitters and biogenic amines in the central nervous system and peripheral tissues, respectively.
In the process of oxidative deamination, aldehydes, hydrogen peroxide, and ammonia are constantly generated as potential deleterious by-products.
While being systematically studied for decades as sources of reactive oxygen species in brain diseases, compelling evidence nowadays supports the role of MAO-related oxidative stress in cardiovascular and metabolic pathologies.
Indeed, oxidative stress and chronic inflammation are the most common pathomechanisms of the main noncommunicable diseases of our century.
MAO inhibition with the new generation of reversible and selective drugs has recently emerged as a pharmacological strategy aimed at mitigating both processes.
The aim of this minireview is to summarize available information regarding the contribution of MAO to the vascular oxidative stress and endothelial dysfunction in hypertension, metabolic disorders, and chronic kidney disease, all conditions associated with increased inflammatory burden.
American Psychological Association (APA)
Sturza, Adrian& Popoiu, Călin M.& Ionică, Mihaela& Duicu, Oana M.& Olariu, Sorin& Muntean, Danina M.…[et al.]. 2019. Monoamine Oxidase-Related Vascular Oxidative Stress in Diseases Associated with Inflammatory Burden. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1206012
Modern Language Association (MLA)
Sturza, Adrian…[et al.]. Monoamine Oxidase-Related Vascular Oxidative Stress in Diseases Associated with Inflammatory Burden. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1206012
American Medical Association (AMA)
Sturza, Adrian& Popoiu, Călin M.& Ionică, Mihaela& Duicu, Oana M.& Olariu, Sorin& Muntean, Danina M.…[et al.]. Monoamine Oxidase-Related Vascular Oxidative Stress in Diseases Associated with Inflammatory Burden. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1206012
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206012