![](/images/graphics-bg.png)
Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B1
Joint Authors
Abdel-Daim, Mohamed M.
Alkahtani, Saad
Bin-Jumah, May
Alkahtane, Abdullah A.
Alessia, Mohammed S.
Bungǎu, Simona G.
Almutairi, Bader
Abd Eldaim, Mabrouk Attia
Ahmed, Ali Meawad
Alyousif, Mohamed S.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The current study was carried out to evaluate the ameliorative effect of fucoidan against aflatoxicosis-induced hepatorenal toxicity in streptozotocin-induced diabetic rats.
Sixty-four Wister albino male rats were randomly assigned into eight groups (8 rats each) that received normal saline, fucoidan (FUC) at 100 mg/kg/day orally for 4 weeks, streptozotocin (STZ) at 50 mg/kg/i.p.
single dose, STZ plus FUC, aflatoxin B1 (AFB1) at 50 μg/kg/i.p.
after one month of the beginning of the experiment for 2 weeks, AFB1 plus FUC, STZ plus AFB1, or STZ plus AFB1 and FUC.
Injection of rats with STZ induced hyperglycemia.
Rats with STZ-induced diabetes, with or without AFB1 intoxication, had significantly elevated activities of serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase, and levels of serum urea, creatinine, cholesterol, 8-oxo-2′-deoxyguanosine, interleukin-1β, interleukin-6, and tumor necrosis factor-α.
In addition, these rats exhibited increased lipid peroxidation and reduced glutathione concentration and activities of superoxide dismutase, catalase, and glutathione peroxidase enzymes in the hepatic and renal tissues.
In contrast, administration of FUC to diabetic rats, with or without AFB1 intoxication, ameliorated the altered serum parameters, reduced oxidative stress, DNA damage, and inflammatory biomarkers, and enhanced the antioxidant defense system in the hepatic and renal tissues.
These results indicated that FUC ameliorated diabetes and AFB1-induced hepatorenal injuries through alleviating oxidative stress, DNA damage, and inflammation.
American Psychological Association (APA)
Alessia, Mohammed S.& Alkahtani, Saad& Abd Eldaim, Mabrouk Attia& Ahmed, Ali Meawad& Bungǎu, Simona G.& Almutairi, Bader…[et al.]. 2020. Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B1. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1206013
Modern Language Association (MLA)
Alessia, Mohammed S.…[et al.]. Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B1. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1206013
American Medical Association (AMA)
Alessia, Mohammed S.& Alkahtani, Saad& Abd Eldaim, Mabrouk Attia& Ahmed, Ali Meawad& Bungǎu, Simona G.& Almutairi, Bader…[et al.]. Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B1. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1206013
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206013