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Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans
Joint Authors
Tencomnao, Tewin
Wink, Michael
Duangjan, Chatrawee
Rangsinth, Panthakarn
Gu, Xiaojie
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-02
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Anacardium occidentale (AO) contains a number of polyphenolic secondary metabolites with antioxidant activity.
The objectives of this study were aimed at investigating the roles of AO leaf extracts in antioxidative stress and longevity, as well as their underlying mechanisms, in the Caenorhabditis elegans (C.
elegans) model.
AO extracts mediated the survival rate of nematodes under oxidative stress by attenuating intracellular reactive oxygen species (ROS) via the DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways.
AO extracts stimulated the expression of stress response genes including SOD-3 and GST-4.
Moreover, AO extracts exhibited antiaging activities and enhanced longevity.
We observed improved pharyngeal pumping function, attenuation of pigment accumulation (lipofuscin), and an increased lifespan of the worms.
Collectively, our results demonstrated that AO extracts exerted both oxidative stress resistance and antiaging properties in the C.
elegans model and may lead to new agents to benefit humans in the near future.
American Psychological Association (APA)
Duangjan, Chatrawee& Rangsinth, Panthakarn& Gu, Xiaojie& Wink, Michael& Tencomnao, Tewin. 2019. Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1206021
Modern Language Association (MLA)
Duangjan, Chatrawee…[et al.]. Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1206021
American Medical Association (AMA)
Duangjan, Chatrawee& Rangsinth, Panthakarn& Gu, Xiaojie& Wink, Michael& Tencomnao, Tewin. Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1206021
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206021