MicroRNA-874-3p Aggravates Doxorubicin-Induced Renal Podocyte Injury via Targeting Methionine Sulfoxide Reductase B3
Joint Authors
Dai, Yan
Gao, Meng
Li, Linxia
Mao, Zhang
Xu, Lina
Yin, Lianhong
Qi, Yan
Peng, J.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-18
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Clinical application of doxorubicin (Dox) is limited due to its serious side effects including nephrotoxicity, and kidney podocytes play important roles in renal diseases.
MicroRNAs (miRNAs) are critical regulators associated with human diseases.
The purpose of this study was to explore a novel target in adjusting Dox-induced renal podocyte injury.
Through a double luciferase reporter gene experiment, it was found that miR-874-3p directly targeted methionine sulfoxide reductase B3 (MsrB3).
During the tests of miR-874-3p inhibitor and MsrB3 siRNA in human podocytes or miR-874-3p antagomir in mice, we found that the expression levels of downstream oxidative stress and apoptosis-related proteins were regulated by miR-874-3p/MsrB3 signal to alleviate or aggravate renal podocyte injury.
The data in the present work showed that miR-874-3p aggravated Dox-caused renal podocyte injury by promoting apoptosis and oxidative damage via inhibiting MsrB3.
Therefore, miR-874-3p/MsrB3 should be considered as a new therapeutic target in controlling renal podocyte injury induced by Dox.
American Psychological Association (APA)
Dai, Yan& Gao, Meng& Li, Linxia& Mao, Zhang& Xu, Lina& Yin, Lianhong…[et al.]. 2020. MicroRNA-874-3p Aggravates Doxorubicin-Induced Renal Podocyte Injury via Targeting Methionine Sulfoxide Reductase B3. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1206056
Modern Language Association (MLA)
Dai, Yan…[et al.]. MicroRNA-874-3p Aggravates Doxorubicin-Induced Renal Podocyte Injury via Targeting Methionine Sulfoxide Reductase B3. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-18.
https://search.emarefa.net/detail/BIM-1206056
American Medical Association (AMA)
Dai, Yan& Gao, Meng& Li, Linxia& Mao, Zhang& Xu, Lina& Yin, Lianhong…[et al.]. MicroRNA-874-3p Aggravates Doxorubicin-Induced Renal Podocyte Injury via Targeting Methionine Sulfoxide Reductase B3. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1206056
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206056