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ROS-Mediated Cancer Cell Killing through Dietary Phytochemicals
Joint Authors
NavaneethaKrishnan, Saranya
Rosales, Jesusa L.
Lee, Ki-Young
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-14
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Reactive oxygen species (ROS) promote carcinogenesis by inducing genetic mutations, activating oncogenes, and raising oxidative stress, which all influence cell proliferation, survival, and apoptosis.
Cancer cells display redox imbalance due to increased ROS level compared to normal cells.
This unique feature in cancer cells may, therefore, be exploited for targeted therapy.
Over the past few decades, natural compounds have attracted attention as potential cancer therapies because of their ability to maintain cellular redox homeostasis with minimal toxicity.
Preclinical studies show that bioactive dietary polyphenols exert antitumor effects by inducing ROS-mediated cytotoxicity in cancer cells.
These bioactive compounds also regulate cell proliferation, survival, and apoptotic and antiapoptotic signalling pathways.
In this review, we discuss (i) how ROS is generated and (ii) regulated and (iii) the cell signalling pathways affected by ROS.
We also discuss (iv) the various dietary phytochemicals that have been implicated to have cancer therapeutic effects through their ROS-related functions.
American Psychological Association (APA)
NavaneethaKrishnan, Saranya& Rosales, Jesusa L.& Lee, Ki-Young. 2019. ROS-Mediated Cancer Cell Killing through Dietary Phytochemicals. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1206059
Modern Language Association (MLA)
NavaneethaKrishnan, Saranya…[et al.]. ROS-Mediated Cancer Cell Killing through Dietary Phytochemicals. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1206059
American Medical Association (AMA)
NavaneethaKrishnan, Saranya& Rosales, Jesusa L.& Lee, Ki-Young. ROS-Mediated Cancer Cell Killing through Dietary Phytochemicals. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1206059
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206059