Reactive Astrogliosis: Implications in Spinal Cord Injury Progression and Therapy
Joint Authors
Li, Xinyu
Li, Meng
Tian, Lige
Chen, Jianan
Liu, Ronghan
Ning, Bin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-20
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Astrocytes are the most populous glial cells in the central nervous system (CNS).
They are essential to CNS physiology and play important roles in the maintenance of homeostasis, development of synaptic plasticity, and neuroprotection.
Nevertheless, under the influence of certain factors, astrocytes may also exert detrimental effects through a process of reactive astrogliosis.
Previous studies have shown that astrocytes have more than one type of polarization.
Two types have been extensively researched.
One is a damaging change that occurs under inflammation and has been termed A1 astrocyte, while the other is a restorative change that occurs under ischemic induction and was termed A2 astrocyte.
Researchers are now increasingly paying attention to the role of astrocytes in spinal cord injury (SCI), degenerative diseases, chronic pain, neurological tumors, and other CNS disorders.
In this review, we discuss (a) the characteristics of polarized astrocytes, (b) the relationship between astrocyte polarization and SCI, and (c) new implications of reactive astrogliosis for future SCI therapies.
American Psychological Association (APA)
Li, Xinyu& Li, Meng& Tian, Lige& Chen, Jianan& Liu, Ronghan& Ning, Bin. 2020. Reactive Astrogliosis: Implications in Spinal Cord Injury Progression and Therapy. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1206063
Modern Language Association (MLA)
Li, Xinyu…[et al.]. Reactive Astrogliosis: Implications in Spinal Cord Injury Progression and Therapy. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1206063
American Medical Association (AMA)
Li, Xinyu& Li, Meng& Tian, Lige& Chen, Jianan& Liu, Ronghan& Ning, Bin. Reactive Astrogliosis: Implications in Spinal Cord Injury Progression and Therapy. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1206063
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206063