Cell Senescence: A Nonnegligible Cell State under Survival Stress in Pathology of Intervertebral Disc Degeneration
Joint Authors
Yang, Biao
Gong, Zhe
Yu, Chao
Cheng, Feng
Zhang, Yuang
Wang, Chenggui
Wang, Jingkai
Shi, Kesi
Ying, Liwei
Xia, Kaishun
Huang, Xianpeng
Li, Fangcai
Liang, Chengzhen
Chen, Qixin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The intervertebral disc degeneration (IDD) with increasing aging mainly manifests as low back pain (LBP) accompanied with a loss of physical ability.
These pathological processes can be preliminarily interpreted as a series of changes at cellular level.
In addition to cell death, disc cells enter into the stagnation with dysfunction and deteriorate tissue microenvironment in degenerative discs, which is recognized as cell senescence.
During aging, many intrinsic and extrinsic factors have been proved to have strong connections with these cellular senescence phenomena.
Growing evidences of these connections require us to gather up critical cues from potential risk factors to pathogenesis and relative interventions for retarding cell senescence and attenuating degenerative changes.
In this paper, we try to clarify another important cell state apart from cell death in IDD and discuss senescence-associated changes in cells and extracellular microenvironment.
Then, we emphasize the role of oxidative stress and epigenomic perturbations in linking risk factors to cell senescence in the onset of IDD.
Further, we summarize the current interventions targeting senescent cells that may exert the benefits of antidegeneration in IDD.
American Psychological Association (APA)
Zhang, Yuang& Yang, Biao& Wang, Jingkai& Cheng, Feng& Shi, Kesi& Ying, Liwei…[et al.]. 2020. Cell Senescence: A Nonnegligible Cell State under Survival Stress in Pathology of Intervertebral Disc Degeneration. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1206065
Modern Language Association (MLA)
Zhang, Yuang…[et al.]. Cell Senescence: A Nonnegligible Cell State under Survival Stress in Pathology of Intervertebral Disc Degeneration. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1206065
American Medical Association (AMA)
Zhang, Yuang& Yang, Biao& Wang, Jingkai& Cheng, Feng& Shi, Kesi& Ying, Liwei…[et al.]. Cell Senescence: A Nonnegligible Cell State under Survival Stress in Pathology of Intervertebral Disc Degeneration. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1206065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206065