Understanding Diabetic Neuropathy: Focus on Oxidative Stress
Joint Authors
Cai, Yin
Ma, Haichun
Pang, Lei
Lian, Xin
Liu, Huanqiu
Zhang, Yuan
Li, Qian
Yu, Xin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Diabetic neuropathy is one of the clinical syndromes characterized by pain and substantial morbidity primarily due to a lesion of the somatosensory nervous system.
The burden of diabetic neuropathy is related not only to the complexity of diabetes but also to the poor outcomes and difficult treatment options.
There is no specific treatment for diabetic neuropathy other than glycemic control and diligent foot care.
Although various metabolic pathways are impaired in diabetic neuropathy, enhanced cellular oxidative stress is proposed as a common initiator.
A mechanism-based treatment of diabetic neuropathy is challenging; a better understanding of the pathophysiology of diabetic neuropathy will help to develop strategies for the new and correct diagnostic procedures and personalized interventions.
Thus, we review the current knowledge of the pathophysiology in diabetic neuropathy.
We focus on discussing how the defects in metabolic and vascular pathways converge to enhance oxidative stress and how they produce the onset and progression of nerve injury present in diabetic neuropathy.
We discuss if the mechanisms underlying neuropathy are similarly operated in type I and type II diabetes and the progression of antioxidants in treating diabetic neuropathy.
American Psychological Association (APA)
Pang, Lei& Lian, Xin& Liu, Huanqiu& Zhang, Yuan& Li, Qian& Cai, Yin…[et al.]. 2020. Understanding Diabetic Neuropathy: Focus on Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1206074
Modern Language Association (MLA)
Pang, Lei…[et al.]. Understanding Diabetic Neuropathy: Focus on Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1206074
American Medical Association (AMA)
Pang, Lei& Lian, Xin& Liu, Huanqiu& Zhang, Yuan& Li, Qian& Cai, Yin…[et al.]. Understanding Diabetic Neuropathy: Focus on Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1206074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206074